Delta-Processing (DP) is a suitable heat treatment process aiming at controlling grain growth during hot deformation of the well-known Ni-base superalloy Inconel 718 (IN718). DP often applied by heating up to 900 °C for 24 h in order promote δ-phase saturation prior deformation. In addition δ-phase, Mo and Cr-rich carbides form M23C6 may also precipitate subsequent this alloy range 950–1000 The...

Given a probabilistic graphical model, its density of states is a distribution that, for any likelihood value, gives the number of configurations with that probability. We introduce a novel message-passing algorithm called Density Propagation (DP) for estimating this distribution. We show that DP is exact for tree-structured graphical models and is, in general, a strict generalization of both s...

Invariant Valpha14i NKT (iNKT) cells are a specialized subset of T lymphocytes with regulatory functions. They coexpress TCRalphabeta and natural killer cell markers. They differentiate through interaction of their Valpha14-Jalpha18 invariant TCRalpha chains with CD1d expressed on double-positive (DP) thymocytes. Although their development has been shown to be thymus dependent, their developmen...

Self versus non-self discrimination is a key feature of immunorecognition. Through TCR-activated apoptotic mechanisms, autoreactive thymocytes are purged at the CD4(+)CD8(+) double-positive (DP) precursor stage prior to maturation to CD4(+) or CD8(+) single-positive (SP) thymocytes. To investigate this selection process in vivo, gene expression analysis by oligonucleotide array was performed in...

Determination of a nonlinear system is more difficult than a linear system because of the requirement to reconstruct composed elements. The cochlea is a frequency analyzer in our ear and shows nonlinearities such as two-tone suppression (2TS) and distortion product (DP) for two tones. In the psychological and clinical studies, those nonlinearities have been also measured. However, accurate meas...

BACKGROUND AND OBJECTIVES To compare the effectiveness of monitoring cisplatin-induced ototoxicity in adult patients using extended high-frequency pure-tone audiometry (EHF-PTA) or distortion-product otoacoustic emission (DP-OAE) and to evaluate the concurrence of ototoxicity and nephrotoxicity in cisplatin-treated patients. SUBJECTS AND METHODS EHF-PTA was measured at frequencies of 0.25, 0....

Ag receptor loci are regulated to promote allelic exclusion, but the mechanisms are not well understood. Assembly of a functional TCR β-chain gene triggers feedback inhibition of V(β)-to-DJ(β) recombination in double-positive (DP) thymocytes, which correlates with reduced V(β) chromatin accessibility and a locus conformational change that separates V(β) from DJ(β) gene segments. We previously g...

Abstract Lead halide perovskite nanocrystals (NCs) have recently drawn considerable attention in the fields of materials science and nanotechnology. However, a major drawback these NCs is reliance on toxic lead, which hinders widespread application. Herein, new class lead‐free NCs, that is, lanthanide double (Ln‐DP) with f‐orbital‐induced optical properties, introduced. The Pr‐, Ce‐, Tb‐, Eu‐, ...

Introduction: Dynamic contrast enhanced MRI (DCE-MRI) with tracer kinetic modeling has been proposed as a biomarker of tumor angiogenesis assessment in humans. Several tracer kinetic models, distributed parameter model (DP), St. Lawrence and Lee model (ATH), and conventional compartmental model (CC), have been proposed to calculate permeability-surface area product (PS). It was found that PS co...

the binding of drugs by plasma proteins is an important phenomenon, because it influences the size of the free fraction of the drugs in plasma. in this study the influence of dipyridamole (dp) on the protein binding of propranolol (pl) and pl on the protein binding of dp were studied alone and in the presence of nicotine (nc).        the equilibrium dialysis was employed for protein binding stu...