Group II chaperonins are ATP-dependent ring-shaped complexes that bind nonnative polypeptides and facilitate protein folding in archaea and eukaryotes. A built-in lid encapsulates substrate proteins within the central chaperonin chamber. Here, we describe the fate of the substrate during the nucleotide cycle of group II chaperonins. The chaperonin substrate-binding sites are exposed, and the li...

One-shot neural architecture search (NAS) substantially improves the efficiency by training one supernet to estimate performance of every possible child (i.e., subnet). However, inconsistency characteristics among subnets incurs serious interference in optimization, resulting poor ranking correlation subnets. Subsequent explorations decompose weights via a particular criterion, e.g., gradient m...

BACKGROUND Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil/U-MDT/CT-BR is suitable to evaluate its prog...

introduction: analysis of smile is one of the esthetic evaluations in dentistry. in the present study, gla, lid, the long axis position and the oblique axial angle of each tooth were evaluated. materials and methods: in this cross-sectional analytical study, 80 subjects with properly-aligned teeth and healthy periodontium were selected. a digital camera was to take photos of lip areas in unifor...

Treating unilateral ptosis can be challenging and a proper preoperative evaluation may help prevent unexpected outcomes on the contralateral lid. Preoperative evaluation should include testing for Hering's law, which remains useful in understanding the phenomenon of induced contralateral eyelid retraction in the context of ptosis. Approximately 10% to 20% of patients with unilateral ptosis have...

Group II chaperonins found in archaea and in eukaryotic cytosol mediate protein folding without a GroES-like cofactor. The function of the cofactor is substituted by the helical protrusion at the tip of the apical domain, which forms a built-in lid on the central cavity. Although many studies on the change in lid conformation coupled to the binding and hydrolysis of nucleotides have been conduc...

We report on an atomistic molecular dynamics simulation of the complete conformational transition of Escherichia coli adenylate kinase (ADK) using the recently developed TEE-REX algorithm. Two phases characterize the transition pathway of ADK, which folds into the domains CORE and LID and the AMP binding domain AMPbd. Starting from the closed conformation, half-opening of the AMPbd precedes a p...

Recently, we have proposed a parallel sub-word recognition (PSWR) system for language identification (LID) in a framework similar to the parallel phone recognition (PPR) approach in the literature, but without requiring phonetic labeling of the speech data in any of the languages in the LID task. In this paper, we show the theoretical equivalence of PSWR and ergodicHMM (E-HMM) based LID. Here, ...

introduction: aim of the study was to determine the efficacy of minor lateral tarsorrhaphy in conjunction with levator muscle recession in thyroid ophthalmopathic patients with severe lid retraction in order to correct the temporal flare in these patients methods: in a before-after clinical trial study, 22 eyelids of 12 patients with severe lid retraction underwent surgery by this method and th...

BACKGROUND Gastrodia elata Blume (GEB), commonly used medicinal herb, has been reported as a promising candidate for neurodegenerative diseases such as Parkinson's disease. The dopamine precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), is the gold-standard drug for Parkinson's disease, but long-term treatment results in the L-dopa-induced dyskinesia (LID). This study was undertaken to examine t...