Craniospinal irradiation (CSI) using IMRT allows dose sparing to organs-at-risk (OAR) whilst conforming the dose to the target volume. Due to the complexity of treatment involving several isocenters, the dose distribution created by the inverse-planned segmented fields must be verified prior to treatment. We propose and test methods to verify dose delivery using commonly available dosimetry equ...

Introduction: Computerized treatment planning is a rapidly evolving modality that depends on hardware and software efficiency. Despite ICRU recommendations suggesting 5% deviation in dose delivery the overall uncertainty shall be less than 3.5% as suggested by B.J. Minjnheer. J. In house spreadsheets are developed by the medical physicists to cross-verify the dose calculated by the Treatment Pl...

the supersaturatable self-microemulsifying drug delivery system (s-smedds) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. the supersatur...

background: the poor permeability of the plasma and nuclear membranes to dna plasmids are two major barriers for the development of these therapeutic molecules. therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. objectives: the aim of this study was to investigate the in vitro delivery of plasmid dna encoding hpv16 e7 gene ...

Copyright © 2010 Frederick Furness Publishing 14 Oral delivery continues to be the most popular route of administration due to its versatility, ease of administration and probably most importantly patient compliance. In a recent New England Healthcare Institute report, the cost of non-compliance in the US alone was estimated to be as much as $290 billion, or 13% of total annual health care expe...