methanolic extract of whole plant of amaranthus viridis l (meav), was screened for antinociceptive activity using acetic acid induced writhing test, hot plate test and tail immersion test in mice. in a similar way a screening exercise was carried out to determine the antipyretic potential of the extract using yeast induced pyrexia method in rats. administration of the extracts was applied to bo...

context appropriate management of neonates, tested positive for congenital hypothyroidism (ch), in particular, the initial dosage of levothyroxine and the time of initiation of treatment is a critical issue. the aim of this study was to assess all current evidence available on the subject to ascertain the optimal initial dose and optimal initiation time of treatment for children with ch. eviden...

background: hepatitis b virus (hbv) vaccination is a well-known, safe and effective way for protection against hbv infection; however, non-responders remain susceptible to infection with hbv. this is so important in patients with any kind of chronic liver disease, especially chronic hepatitis c virus (hcv) patients in whom acute hbv infection may lead to decompensation of liver disease. some of...

introduction: gamma knife is an instrument specially designed for treating brain disorders. in gamma knife, there are 201 narrow beams of cobalt-60 sources that intersect at an isocenter point to treat brain tumors. the tumor is placed at the isocenter and is treated by the emitted gamma rays. therefore, there is a high dose at this point and a low dose is delivered to the normal tissue surroun...

introduction: skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using varskin2. materials and methods: in this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90sr/90y, 147pm, 32p beta emitter radioisotopes by using input parameters: activity of source, ...

introduction:  all of  the  people worldwide  are exposed  to  low levels  of  radiation. cancer induction  and  genetic disorders are among the hazards of low level exposure. in some cases, radiation close to hot springs is  higher than normal areas due to a high concentration and the decay products of ra-226. given the use of hot  springs by the general public  because  of their therapeutic p...

introduction evaluation of the delivered dose of externally wedged photon beams by external diode dosimeters during the treatment process requires the estimation of exit surface dose correction factors in various wedge angles and field sizes. materials and methods a system of absorbed dose evaluation, using p-type diode dosimeters placed on the exit surface of a phantom, was characterized for e...

introduction high doses of ionizing radiation can lead to adverse health outcomes such as cancer induction in humans. although the consequences are less evident at very low radiation doses, the associated risks are of societal importance. this study aimed at assessing entrance skin doses (esds) in patients undergoing selected diagnostic x-ray examinations at public hospitals of akwa ibom state,...

objective(s): although tumor necrosis factor-related apoptosis-inducing ligand (trail) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (nsclc) exhibit trail-resistance. the purpose of this study was to determine whether subtoxic-dose cisplatin and trail could synergistically enhance apoptosis on nsclc cells and investigate its under...

selective serotonin reuptake inhibitors (ssris) are reported to be associated with increased bleeding tendency. while findings of recent studies explain a lot about the pathophysiology of this side-effect, there is a general tendency to discontinue ssris as harmful medications. we report two instances of dose-dependent relations between sertraline and bleeding tendency. bleeding diathesis was a...