Despite the importance and significant clinical impact of understanding information processing in the nociceptive system, the functional properties of neurons in many parts of this system are still unknown. In this work we performed whole cell patch-clamp recording in rat brain stem blocks to characterize the electrophysiological properties of neurons in the dorsal reticular nucleus (DRt), a re...

Coordinated cell movements contribute to the shaping of developing organisms during morphogenesis. Understanding the molecular basis of these directed movements is a crucial part of understanding the mechanisms in action during development. We present here a cellular description of two morphogenetic processes: dorsal closure of the Drosophila embryo and convergent extension in two vertebrate mo...

When performing sequences of actions, we constantly keep track of our current position in the sequence relative to the overall goal. The present study searched for neural representations of sequence progression in corticostriatal circuits. Neurons within the anterior cingulate cortex (ACC) and its target region in the dorsal striatum (DS) were recorded from simultaneously as rats performed diff...

The serotoninergic system and the 5-HT1A receptors have been involved in the brain response to acute stress. The aim of our study was evaluate the role of the 5-HT1A receptors in serotoninergic cells of rostral and caudal raphe nuclei under acute immobilization in rats. Double immunocytochemical staining of 5-hydroxy-tryptamine and c-Fos protein and stereology techniques were used to study the ...

We explored here the hypothesis that temporary chronic water restriction in mice affects social behavior, via its action on density of 5-HT neurons dorsal and median raphe nuclei (DRN MRN). For that, we submitted adult C57BL/6 J to mild controlled dehydration, i.e., 6 h access every 48 for 15 days. investigated their behavior a interaction task known allow free reciprocal contact. Results showe...

We showed that when CA3 pyramidal neurons in the caudal 80% of the dorsal hippocampus had almost disappeared completely, the efferent pathway of CA3 was rarely detectable. We used the mouse pilocarpine model of temporal lobe epilepsy (TLE), and injected iontophoretically the anterograde tracer phaseolus vulgaris leucoagglutinin (PHA-L) into gliotic CA3, medial septum and the nucleus of diagonal...

Abstract —The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not fully understood. To further clarify role brain serotonergic (5-HT) activity action drugs, optogenetic inhibition 5-HT neurons rat dorsal raphe nucleus (DRN) was applied. In control animals, a subanesthetic dose alleviated their depressive-like behavior tail suspension test. Inhibit...