نتایج جستجو برای: dominant gain
تعداد نتایج: 295026 فیلتر نتایج به سال:
It is unclear whether mutations in fused in sarcoma (FUS) cause familial amyotrophic lateral sclerosis via a loss-of-function effect due to titrating FUS from the nucleus or a gain-of-function effect from cytoplasmic overabundance. To investigate this question, we generated a series of independent Caenorhabditis elegans lines expressing mutant or wild-type (WT) human FUS. We show that mutant FU...
We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutations that define the seventh gene, lag-2, are semi-dominant suppressors. These...
We have previously described the gene mei-1, which encodes an essential component of the Caenorhabditis elegans meiotic spindle. When ectopically expressed after the completion of meiosis, mei-1 protein disrupts the function of the mitotic cleavage spindles. In this article, we describe the cloning and the further genetic characterization of mel-26, a postmeiotic negative regulator of mei-1. me...
Maize (Zea mays) leaves provide a useful system to study how proximal/distal patterning is established because of the distinct tissues found in the distal blade and the proximal sheath. Several mutants disrupt this pattern, including the dominant knotted1-like homeobox (knox) mutants. knox genes encode homeodomain proteins of the TALE superclass of transcription factors. Class I knox genes are ...
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The paper presents the “Turntable”, a 3D input device for orienting objects using the non-dominant hand. The device supports two-handed manipulation by allowing the non-dominant hand to orient an object while leaving the dominant hand free to perform other actions. Two-handed input is a technique that can enhance the performance, simplicity and intuitiveness of CAD systems. These properties are...
Abstract The selective hydrogenation of octyne in a mixed 1‐octyne/1‐octene feed was investigated by employing Pd/Al 2 O 3 and PdAg/Al catalysts coated with 1‐butyl‐3‐methylimidazolium dicyanamide ([BMIM][DCA]) as SCILLs (Solid Catalysts an Ionic Liquid Layer). All were compared to organically modified, 1‐ethylimidazole (EIM) catalyst determine if there is SCILL effect. Results the catalysis sh...
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