OBJECTIVE This article provides a comprehensive review of the healthcare reform process driven by the Vietnamese Ministry of Health's Direction of Healthcare Activities (DOHA) scheme. METHODS We reviewed policy documents relating to DOHA, along with historical literature and background information describing its formation. RESULTS DOHA (Chỉ đạo tuyến in Vietnamese) literally means guidance ...

The DNA damage response (DDR) is a set of cellular events that follows the generation of DNA damage. Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNAs), have been shown to play a role in DDR signalling and DNA repair. Dysfunctional telomeres activate DDR in ageing, cancer and an increasing number of identified pathological conditions. Here we show that,...

The polycomb group protein BMI1 is a component of the polycomb repressive complex 1 (PRC1). Although lacking enzymatic activity, BMI1 makes an important contribution to the intrinsic E3 ubiquitin ligase activity of PRC1 via binding of the catalytic subunit RING2. PRC1 catalyzes mono-ubiquitination of histone H2A at lysine 119 (H2AK119Ub), a well-recognized epigenetic marker associated with gene...

The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication. To define the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host's DNA damage response (DDR) and apoptosis. We report here that AcMNPV elicits a DDR in the model insect Dro...

Discoidin domain receptors (DDRs) are receptor tyrosine kinases that are activated by native collagens and have an important role during cell adhesion, development, differentiation, proliferation, and migration. DDR deregulation is associated with progression of several different cancers. However, there is limited information about the role of DDRs in the progression of breast cancer. In this r...

BACKGROUND AND AIM: Digital panoramic X-ray images can be captured using photostimulable phosphors or solid-state detectors (i.e. charge-coupled devices and Flat-Panels). The first category is defined as computed radiography (CR) or semi-direct radiography. The second technology that uses solid-state detectors is known as direct digital radiography (DDR). Both of these technologies have their o...

Cells have evoked mechanisms, globally named the DNA damage response (DDR), to detect, signals and repair DNA lesions, which are tightly coordinated with apoptotic or cell cycle arrest responses [1]. Defects in these mechanisms lead to genomic instability, a hallmark of cancer cells. While key components of DDR have now been identified, further research is required to determine how these compon...