Purpose: Many anthracycline anticancer drugs contain carbohydrate moieties as a part of their chemical structure. Research studies have suggested that the sugar moiety of these anthracyclines play an important role in determining the biological and pharmacological activities of the drug. The clinical application of anthracycline antibiotics, daunorubicin (DNR) and doxorubicin is limited by the ...

We have compared multiple assays for the P-glycoprotein (Pgp/MDR1) phenotype in fresh and thawed adult acute leukemia to validate and quantitate measures for the expression and function of Pgp. The results are related to the Pgp-expressing KB8 and KB8-5 call lines. The most sensitive assay was the measurement of modulation of the rhodamine 123 (R123) fluorescence by 2 micromol/L PSC833, followe...

BACKGROUND In an environment characterized by cuts to health care, hospital closures, increasing reliance on home care and an aging population, more terminally ill patients are choosing to die at home. The authors sought to determine the care received by these patients when paramedics were summoned by a 911 call and to document whether do-not-resuscitate (DNR) requests influenced the care given...

Cardiopulmonary resuscitation (CPR) has the ability to reverse premature death. It can also prolong terminal illness, increase discomfort and consume enormous resources. Despite the desire to respect patient autonomy, there are many reasons why withholding CPR may be complicated in the perioperative setting. This review outlines these factors in order to offer practical suggestions and to provo...

One of the most famous methods for minimizing power loss is distribution network reconfiguration (DNR). Accordingly, many researchers have focused their work on finding a network’s optimal configuration in planning mode. However, few address switching sequence process during operation This paper introduces an innovative approach to minimize networks. It addresses often-overlooked real-time orde...

In Reverse Mathematics, the axiom system DNR, asserting the existence of diagonally non-recursive functions, is strictly weaker than WWKL0 (weak weak König’s

Do Not Resuscitate (DNR) merupakan keputusan klinis yang sering menjadi dilema etik, moral, dan hukum bagi para tenaga medis. Penelitian bertujuan untuk memberikan gambaran faktor mempengaruhi DNR bagaimana konsekuensi hukumnya di Indonesia ketika terpaksa dipilih. menggunakan metode yuridis empiris berdasarkan rekam medis beberapa pasien dengan masing-masing diagnosis berbeda dirawat Instalasi...

Extensive bioethics literature discusses DNR orders, but comparatively little has been published on a topic that involves almost every aspect of end-of-life decision making: DNR orders in patients who attempt suicide. Ethics consultants are increasingly confronted with this dilemma in an area where there is little legal guidance or ethical consensus. A case-based analysis of the arguments for a...