Aiming to address the complex degenerate primer design problem in biological field, this paper, we a optimization model considering coverage and degeneracy that allows small number of base mismatches, propose global method based on artificial bee colony algorithm. The proposed algorithm combines idea ant with process algorithm, overcomes disadvantage uncertain candidate solution length solving ...

Using a DNA polymerase to record intracellular calcium levels has been proposed as a novel neural recording technique, promising massive-scale, single-cell resolution monitoring of large portions of the brain. This technique relies on local storage of neural activity in strands of DNA, followed by offline analysis of that DNA. In simple implementations of this scheme, the time when each nucleot...

methylated and un-methylated control dna is an important part of dna methylation studies. although human and mouse dna methylation control sets are commercially available, in case of methylation studies on other species such as animals, plants, and bacteria, control sets need to be prepared. in this paper a simple method of generating methylated and un-methylated control dna is described. whole...

Discrimination of protein coding regions called exons from noncoding regions called introns or junk DNA in eukaryotic cell is a computationally intensive task. But the dimension of the DNA string is huge; hence it requires large computation time. Further the DNA sequences are inherently random and have vast redundancy, hidden regularities, long repeats and complementary palindromes and therefor...

Punctual identification of protein-coding regions in Deoxyribonucleic Acid (DNA) sequences because of their 3-base periodicity has been a challenging issue in bioinformatics. Many DSP (Digital Signal Processing) techniques have been applied for identification task and concentrated on assigning numerical values to the symbolic DNA sequence and then applying spectral analysis tools such as the sh...

Color visualization of the DNA diverse living beings can help in exploration issue chromatic differentiation functional mappings nucleotide composition molecules. By “chromatic differentiation”, we mean coloring these mappings. Algorithms for genetic representations improve perception complex information using color. Methodologically, to build DNA, employed system Walsh functions and Chaos Game...

objective: the passage of ionizing radiation in living cells creates clusters of damaged nucleotides in dna. in this study, dna strand breaks induced by the beta particle of iodine-131 (i-131), have been determined experimentally and compared to monte carlo simulation results as a theoretical method of determining131i damage. materials and methods: in this experimental study, in order to create...