نتایج جستجو برای: dna واکسن e7
تعداد نتایج: 511899 فیلتر نتایج به سال:
During the last 30 h of the larval stage, the salivary glands of Bradysia hygida show the amplification of some genes, resulting in the formation of two successive groups of DNA puffs, which direct the synthesis of two different sets of polypeptides. Incubation of anterior (S1) salivary gland regions, at age E7, beginning of first group of DNA puffs activity, in culture medium for 2 to 10 h res...
Rb protein is a critical regulator of entry into the cell cycle, and loss of Rb function by deletions, mutations, or interaction with DNA viral oncoproteins leads to oncogenic transformation. We have shown that the human papilloma virus (HPV)-16 E7 gene is sufficient to induce the immortalization of mammary epithelial cells (MECs). Surprisingly, the steady-state level of Rb protein in these imm...
A series of mutations in open reading frames (ORFs) E6 and E7 of bovine papillomavirus type 1 (BPV1) was constructed to analyze the roles of these ORFs in transformation of mouse C127 cells. The mutations were designed to prevent synthesis of specific proteins encoded by these genes. None of the mutations caused a decrease in the focus-forming activity of the full-length viral genome or in the ...
Purpose: Imiquimod is a Toll-like receptor 7 agonist used topically to treat external genital warts and basal cell carcinoma. We examined the combination of topical imiquimod with intramuscular administration of CRT/E7, a therapeutic human papillomavirus (HPV) vaccine comprised of a naked DNA vector expressing calreticulin fused to HPV16 E7. Experimental Design: Using an orthotopic HPV16 E6/E7þ...
Background. A significant number of non-small-cell lung cancers (NSCLC) have human papillomavirus (HPV) DNA integrated in their genome. This study sought to further establish HPV's possible etiologic link to NSCLC by evaluating an immune response to HPV's oncogene, E7, in patients with NSCLC. Patients and Methods. Antibodies (IgG) in serum against E7 for HPV 16 and 18 in 100 patients with NSCLC...
عوارض شدید و کشنده توکسوپلاسموز ضرورت یافتن واکسن موثری علیه این بیماری را مطرح می سازد. از این رو توسعه واکسن های جدید علیه بیماری ضرورت دارد. ایمن سازی با پلاسمید حاوی ژن های کد کننده پروتئین های محافظت کننده، راه کار امید بخشی برای ساخت واکسن به شمار می آید. از این رو تحقیق حاضر با هدف ارزیابی ایمنی زایی پلاسمید کد کننده آنتی ژن gra7 و dna کوکتل حاوی پلاسمیدهای کد کننده آنتی ژن راپتری2 rop و...
در این پروژه به منظور طراحی و ساخت یک dna واکسن موثر علیه کیست هیداتیک با حداقل ساختار ممکن و حداکثر قدرت تحریک ایمنی از توالی کدکننده اپی توپ های خطی آنتی ژن p14-3-3 که ایمونوژن تر می باشد و در اکثر مراحل زندگی انگل و سروتیپ های متعدد با ساختار حفاظت شده وجود داشته و واکسن نوترکیب آن نیز پاسخ ایمنی چشمگیری را علیه کیست هیداتیک نشان داده، جهت کلونینگ در وکتور بیانی pegfp-n1 به جای توالی کدکننده...
BACKGROUND Men who have sex with men (MSM) are at high risk of having anal cancer. Anal high-grade squamous intraepithelial lesion (HSIL) is the precursor of anal cancer. We explored the use of different biomarkers associated with human papillomavirus (HPV) infection and HPV-mediated cell transformation to detect and predict HSIL among HIV-positive and HIV-negative MSM. METHODOLOGY/PRINCIPAL ...
The type-specific persistence of oncogenic human papillomavirus (HPV) is considered to be the true precursor of cervical cancer at which the transcription of the viral oncogenes E6 and E7 is necessary for the malignant transformation and maintenance of the neoplastic state. In the present pilot study, a cohort of 66 women was investigated from a routine office-based screening population who had...
OBJECTIVE Expression of the viral E6/E7 oncogenes of high-risk human papillomaviruses (HR-HPV) is necessary for malignant conversion and maintenance in cervical tissue. In order to determine whether HR-HPV E6/E7 mRNA testing more effectively predicts precancerous lesions and invasive cervical cancer than HR-HPV DNA testing, we aimed to compare triage using HR-HPV E6/E7 mRNA testing by APTIMA HP...
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