objective mitochondrial dna (mtdna) is considered a candidate modifier factor for neuro-degenerative disorders. the most common type of ataxia is friedreich's ataxia (fa). the aim of this study was to investigate different parts of mtdna in 20 iranian fa patients and 80 age-matched controls by polymerase chain reaction (pcr) and automated dna sequencing methods to find any probable point mutati...

â background: hepatitis b is still a major health problem in many parts of the world. in some developing countries the most common cause of chronic hepatitis and liver cirrhosis is hepatitis b virus (hbv). the progression of chronic hepatitis b to cirrhosis andâ  hepatocellular carcinoma (hcc) include such viral factors as genotype c and high levels of serum hbv dna in addition to host factors ...

evidence supports the involvement of nitric oxide (no) in a varity of male reproductive processes such as spermatogenesis, spermiogenesis, sperm motion, sperm metabolism and sperm capacitation. however, low concentration of no is essential in biology and physiology of spermatozoa, but high amounts of no is toxic and has negative effects on sperm functions. on the other hand, it is established t...

use of different pesticides in the agriculture sector, in order to boost crop yield within a short time period and low labor, has been tremendously increased since the last decade. pesticide use has elevated crop yield but has produced a number of pronounced problems regarding environmental and health safety. the continuously deteriorating toxicological effects of these pesticides are not only ...

background: occupational and environmental exposures mostly represent complex mixture of genotoxic agents, however there is a wide variation in the specificity of biomarkers. exploration of correlations among biomarkers contributes to the further progress of molecular cancer epidemiology and to the selection of the optimal biomarkers for the investigation of human exposure to carcinogens. the a...