2, 3-Dimercaptopropane-1-sulfonic acid (DMPS) and meso-2, 3-Dimercaptosuccinic acid (DMSA) are dithiols used to treat humans exposed to methylmercury (CH(3)Hg(+)). After treatment, significant amounts of mercury are eliminated rapidly from the kidneys and are excreted in urine. In the present study, we extended our previous studies by testing the hypothesis that MRP2 mediates the secretion of D...

OBJECTIVE To determine total lead body burden by the Lead mobilization test (LMT) by measuring 4 hours urinary lead excretion in the lead exposed as compared to unexposed industrial workers after administration of 10 mg/Kg of dimercaptosuccinic acid and correlate it with blood lead levels, at Wah district Rawalpindi. METHODS Total 149 males consisting of 87 lead exposed workers and 62 control...

The authors report and discuss a case of bilateral renal artery stenosis in a hypertensive 9 year-old girl that was first suspected with Technetium-dimercaptosuccinic acid renal scintigraphy. The scintigraphy showed signs of acute renal failure while the patient was on enalapril for controlling her hypertension. Bilateral renal artery stenosis was confirmed with computed tomography angiography....

the prevalence of vesicoureteral reflux (vur) among siblings of children with vur has been reported to be from 4.7% to 51%. the incidence of vur in the general population is less than 1% but it is high in risk groups. in a prospective study we started identifying the incidence and severity of vur and renal parenchymal lesions in the siblings of patients known to have urinary tract infection (ut...

The spontaneous and chelator mediated excretion of mercury in urine was investigated in male subjects occupationally exposed to mercury vapour (alkaline battery and chloralkali plants) who did not exhibit any sign of kidney damage. The time course of the spontaneous elimination of mercury in urine was examined in seven workers (age 22-40) who had been removed from exposure to mercury vapour (av...

UNLABELLED Balancing image quality with radiation dose is a goal with every diagnostic procedure requiring radiation. Our institution compared the dosing of (99m)Tc-labeled succimer, commonly referred to as dimercaptosuccinic acid ((99m)Tc-DMSA), to pediatric patients using 2 methods of calculation, body surface area (BSA, the method we used from 2009 to 2010) and body weight (BW, the method we...