PURPOSE To prospectively evaluate the diurnal variation of intraocular pressure (IOP) during unoprostone treatment in 13 healthy volunteers. METHOD IOP was measured by Goldmann applanation tonometry by the same observer every 3 hours from 9 am to 9 am the next morning. Unoprostone was then instilled at 9 am and 9 pm daily for 1 month. After 1 month, IOP was measured again with unoprostone ins...

It is known that marijuana smoking and administration of natural cannabinoids reduce intraocular pressure. However, it has not been established whether the intraocular pressure-lowering effects of cannabinoids are mediated by cannabinoid receptors. Aminoalkylindoles are a new class of cannabimimetics with structures entirely different from those of natural cannabinoids. WIN55212-2, a prototypic...

PURPOSE Elevated intraocular pressure is known to reduce retinal blood flow, although the effect of intraocular pressure on retinal vascular pressures is unknown. Direct measurements of intravascular pressures were taken in the cat retina at various intraocular pressures. METHODS Micropipettes of 2- to 3-microns tip diameter were used in conjunction with a servonull pressure-measuring system ...

PURPOSE To investigate whether diurnal fluctuation in intraocular pressure (IOP) can influence the result of the correlations between IOP-related factors and progression of normal tension glaucoma (NTG). METHODS Glaucoma progression was defined as visual field (VF) progression and changes in the optic disc and/or retinal nerve fiber layer (RNFL). Two different methods were used to evaluate th...

PURPOSE To compare the diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure (IOP) in patients already receiving monotherapy with latanoprost. DESIGN Prospective, open-label, and crossover clinical trial. PARTICIPANTS Twenty-six patients with glaucoma or ocular hypertension (ages, 44-79 years) who were receiving treatment with 0.005% latanoprost once every evenin...

Purpose: To discuss aspects of the pathogenesis of glaucomatous optic neuropathy based on morphologic findings of the glaucomatous optic nerve head and examinations of the cerebrospinal fluid pressure. Methods and results: Findings were: normal pressure and high intraocular pressure glaucoma eyes can show a similar appearance of the optic nerve head. These features are not found in any (other) ...

We examined the relationship of intraocular pressure and the development of one-kidney, one wrapped (perinephritic) hypertension in the dog. Conscious femoral arterial pressure (direct arterial puncture) and intraocular pressure (Schiotz tonometer) were measured weekly before and after the surgical induction of hypertension in 11 healthy male mongrel dogs and before and after unilateral nephrec...

INTRODUCTION Anatomical proximity of the eye and the intracranial space is a fact but the existence of physiological and pathophysiological relationships between them is elusive. The objective of this study was to explore anatomical and pathophysiological interactions between the eye and the intracranial space and to assess clinical utility of intraocular pressure measurement in estimation of i...

PURPOSE To characterize 24-hour variation of intraocular pressure (IOP) in healthy young adults based on the axial length of the eye. METHODS Twenty-four-hour IOP data were collected from nine healthy young adults with hyperopia, age range 18 to 25 years, in a sleep laboratory. Every 2 hours, measurements of IOP were taken in the participants after 5 minutes in the supine position and 5 minut...