OBJECTIVE Tetrahydrobiopterin (BH(4)) is a critical cofactor for nitric oxide (NO) synthesis by NO synthase (NOS). Recently, we demonstrated that disturbed flow produced by partial carotid ligation decreases BH(4) levels in vivo. We therefore aimed to determine whether atherosclerosis induced by disturbed flow is due to BH(4) deficiency and NOS uncoupling and whether increasing BH(4) would prev...

Background: Baekdudaegan was designated in 2005 as a protected area to prevent destruction and conserve. However, there are many disturbed and destroyed areas. The total disturbed area amounts to 25.9 km (0.94%), including 13.4 km (0.49%) in the core area and 12.5 km (0.45%) in the buffer area. This study aims to classify the vegetation types established in the disturbed areas and diagnose the ...

when a jack-up installed at a clay location and then leaves; it can create several meter deep footprints. in case of soft clay, the spudcan may have actually penetrated much deeper than the observed footprints. when the penetrated spudcan is pulled out, much of the soft remolded clay will flow around it and go back into the hole. this event, leaving a deep region of disturbed soil. the disturbe...

Recent data from in vitro, animal, and human studies have shed new light on the positive roles of copper in many aspects of AD. Copper promotes the non-amyloidogenic processing of APP and thereby lowers the Aβ production in cell culture systems, and it increases lifetime and decreases soluble amyloid production in APP transgenic mice. In a clinical trial with Alzheimer patients, the decline of ...

The brightest apparent magnitude examples of ultra luminous infrared galaxies (ULIRG's) are studied here in X-ray, optical, infrared and radio wavelengths. It is is found that they have associated material reaching out to apparent diameters of the order of a degree on the sky. Gas, dust, X-ray material and quasars appear to be ejected from the active nuclei with all objects nearer than their re...

Inflammaging refers to a low-grade pro-inflammatory phenotype which accompanies aging in mammals. The aging process is associated with a decline in autophagic capacity which impairs cellular housekeeping, leading to protein aggregation and accumulation of dysfunctional mitochondria which provoke reactive oxygen species (ROS) production and oxidative stress. Recent studies have clearly indicated...

Music therapy is defined as "the prescribed use of music by a qualified person to effect positive changes in the psychological, physical, cognitive, or social functioning of individuals with health or educational problems" (American Music Therapy Association, 2003). While music therapy is closely aligned with the behavioral sciences, it is distinct in that it bridges art with science. Two publi...

This work provides the rst detailed investigation of the disturbed di usion scheme FOS/C introduced in [17] as a type of di usion distance measure within a graph partitioning framework related to Lloyd's k-means algorithm [14]. After outlining connections to distance measures proposed in machine learning, we show that FOS/C can be related to random walks despite its disturbance. Its convergence...

school, coming to the profession for timeless reasons — because of a physician they admire, or because they want to serve, or because they have suffered or witnessed suffering. Perhaps some lucky ones even today have been called to medicine through the medium of a book. If they have a love of literature, reading may well help them to discover a way to understand and identify with the ambitions,...

Endothelial cells respond to fluid shear stress through mechanotransduction responses that affect their cytoskeleton and cell-cell contacts. Here, endothelial cells were grown as monolayers on arrays of microposts and exposed to laminar or disturbed flow to examine the relationship among traction forces, intercellular forces, and cell-cell junctions. Cells under laminar flow had traction forces...