Solubility and drug dissolution are of crucial importance for drug formulations. Poor water-solubility of drug candidates is a major obstacle in drug development, since the oral route is the most patient convenient and cost effective way to deliver drugs. In some cases the low aqueous solubility may limit the bioavailability when the absorption of the drug is dissolution limited. About 40% of t...

The dissolution kinetics of the cotnn~on crystalline forms of cholesterol (anhydrate and monohydrate) were studied in free and conjugated chenodeoxycholate and ursodeoxycholate solutions by static disk, rotating disk, and powder dissolution techniques. 'The dissolution kinetics of both forms of cholesterol were found to be non-diffusion controlled, i.e., the detachment rate of cholesterol molec...

the potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. in this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. it is worth mentio...

objective(s): the aim of this work was to investigate the effect of the natural and the chemically modified form of cyclodextrins namely; β-cyclodextrin (β-cd) and hydroxypropyl-β-cyclodextrin (hp-β-cd) respectively on the solubility and dissolution rate of aripiprazole; an antipsychotic medication showing poor aqueous solubility.   materials and methods: phase solubility of aripiprazole with t...

The aim of this research project was to investigate a potential standardized test method to characterize the dissolution properties of numerous formulation types available for pulmonary delivery. A commercially available dissolution tester was adapted for use as a testing apparatus by the incorporation of a membrane-containing holder. The holder was designed to enclose previously air-classified...

The dissolution behavior of enamel and synthetic hydroxyapatite in acidic media possessing a high degree of partial saturation was found to be neither simple surface dissolution nor linear with time. Instead, a repetitive, stepwise dissolution pattern was observed. To explain this phenomenon, a model based upon a hypothesis that the crystals dissolve in a synchronized fashion was proposed.

The synchronized cyrstal dissolution hypothesis previously proposed to explain the unusual dissolution behavior of human dental enamel and hydroxyapatite in partially saturated acidic media has been critically examined with dissolution-dialysis transport experiments. The findings are in accord with the hypothesis. A model based upon a variable effective solubility for the hydroxyapatite crystal...

Copyright: © 2013 Tsume Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Dissolution Effect of Gastric and Intestinal pH fora BCS class II drug, Pioglitazone: New in vitro Dissolution System to Predic...

Introduction: Fiber optic technology for dissolution testing has been a topic of interest for many researchers for some years. Josefson, Johansson, and Tortensson 1 published early research in this field in 1988. They explored the feasibility of using UV fiber optics for in-situ dissolution and to overcome sample turbidity interference without filtration. In 1993, Brown and Lin 2 used a single ...