Langerhans cell histiocytosis (LCH) is a rare disease, of unknown pathogenesis, characterized by intense and abnormal proliferation of bone marrow-derived histiocytes (Langerhans cells). It can present both local and systemic manifestations involving bone, skin and mucosal tissue, and internal organs. Three basic clinical forms develop: Letterer-Siwe disease (subacute or acute disseminated form...

Tuberculous septic arthritis is difficult to diagnose. A retrospective analysis was done on patients over 15 years of age who attended Srinagarind Hospital, Khon Kaen, Thailand, between January 1, 1997 and December 31, 2006, whose synovial fluid culture was positive for Mycobacterium tuberculosis. The medical records of 77 patients were reviewed; one-third were in their sixth decade. Comorbid d...

Service Bloc opératoireRéanimation, CHRD Moramanga, Madagascar, Accueil-Triage-Urgences-Réanimation Médicale, Hôpital Joseph Raseta de Befelatanana, CHU Antananarivo Madagascar, Faculté de Médecine d'Antananarivo Madagascar, Service Bloc opératoire-Réanimation, CHU Toamasina Madagascar, Service Bloc opératoire-Réanimation, Chirurgie maxillo-faciale Befelatanana, CHU, Antananarivo, Madagascar, S...

Case report A 17-year-old boy presented with reduced vision in the right eye for 2 months. Best corrected visual acuity (BCVA) was counting fingers 2 m and 6/6 in the right and left eyes, respectively. Intra-ocular pressures were in the right 18 mmHg and left 16 mmHg. Slit lamp examination of the right eye showed mutton fat keratic precipitates and multiple densely vascularized granulomatous le...

Granulomatous disorders include a wide variety of infectious and non-infectious conditions with heterogeneous clinical courses considerable constraints affected organs. We take cutaneous sarcoidosis as model disease to acquire new insights into the pathomechanisms granulomas. combined single-cell high-dimensional spatial transcriptomics fluorescently labeled antibody detection for protein expre...

Generalized granuloma (GA) is an inflammatory benign cutaneous disease of unknown etiology that may manifest different clinical features. The most common presentation or classic form of the disease is flesh colored, annular, grouped papules. They usually are on the extremities especially on the lateral or dorsal surfaces of the fingers, hands, wrists, ankles, and insteps. Several clinical manif...

INTRODUCTON: Many lesions of the jaws contain giant cells, they include Peripheral giant cell granuloma, Central giant cell granuloma, aneurismal bone cyst, brown tumor of hyperparathyroidism and early stage of cherubism. Giant cell granuloma which is a benign bone lesion that occurs mainly in the jaws are not tumor but tumor like conditions, the cause of tumor like condition is chronic truma w...

in patients with malignancy, the common etiologies of granuloma formation are tumor related sarcoid reaction, sarcoidosis, tuberculosis and other granulomatous diseases. often, the finding of granulomas in malignant patients may obscure the primary malignancy or may mislead towards treatment of infectious and other etiologies. hence, their proper recognition and necessary follow up is needed to...