We consider a firm that faces random demand and receives product from a single supplier who faces random supply. The supplier’s availability may be affected by events such as storms, strikes, machine breakdowns, and congestion due to orders from its other customers. In our model, we consider a dynamic environment: the probability of disruption, as well as the demand intensity, can be time depen...

Supply chains often experience significant economic disruptions, as in the case of facility breakdowns, transportation mishaps, natural calamities, and terrorist attacks. We collaborated in a study of such disruptive events as part of an initiative by Sandia National Laboratories. We conducted case studies of three electronics firms and their suppliers to explore underlying aspects of the suppl...

How vision operates efficiently in the face of continuous shifts of gaze remains poorly understood. Recent studies show that saccades cause dramatic, but transient, changes in the spatial and also temporal tuning of cells in many visual areas, which may underly the perceptual compression of space and time, and serve to counteract the effects of the saccades and maintain visual stability.

This chapter has three sections. The first provides an examination of the general notion that the brain distinguishes among amodal linguistic components. The second section attempts to support a more specific claim: Namely, that from a linguistic perspective, agrammatism can, best be reconstructed in syntactic terms. And the third section focuses upon processing disruptions in agrammatism-that ...

We consider a multiperiod system operation problem with two conflicting objectives, minimizing cost and risk. Risk stems from uncertain disruptions to the system during operation. While a general model would hedge against disruptions in each time period, we study special cases in which only a modest number of disruptions occur. To optimize for risk, we employ a convex approximation based on con...

The social zeitgeber theory [Ehlers, C. L., Frank, E., & Kupfer, D. J. (1988). Social zeitgebers and biological rhythms. Archives of General Psychiatry, 45, 948-952] offers an explanation of how life events trigger depressive episodes. According to this theory, life stress leads to mood episodes by causing disruptions in individuals' social routines and, in turn, their biological circadian rhyt...

The environment is a well-established source of damaging or disrupting influences on cellular function. In the past, studies of the mechanisms by which such disruptions occur have focused largely on either direct toxic effects on cellular function at the protein or cell signaling level, or mutagenic effects that impact the genome. In recent years there has been a growing appreciation for the po...

This paper outlines an approach to support decision-makers in designing resilient critical infrastructure (CI) networks. As CIs have become increasingly interdependent disruptions can have far-reaching impacts. We focus on the vulnerability of CIs and the socio-economic systems, in which they are embedded, independent from any initial risk event. To determine which disruptions are the most seve...

High-copy transposon mutagenesis is an effective tool for creating gene disruptions in maize. In order to molecularly define transposon-induced disruptions on a genome-wide scale, we optimized TAIL-PCR to amplify genomic DNA flanking maize Robertson's Mutator insertions. Sample sequencing from 43 Mutator stocks and the W22 inbred line identified 676 non-redundant insertions, and only a small fr...

The paper describes the detection of the m/n = 2/1 disruption precursor at TEXTOR. This frequently observed precursor is detected by realtime cross-correlation of two radially separated channels of the heterodyne electron cyclotron emission diagnostic. An electronic module developed to detect the precursor and its functionality is briefly described. A disruption statistic for TEXTOR is presente...