background: psychologically traumatic workplace events (known as critical incidents), which occur globally, are increasing in prevalence within the usa. assisting employers in their response is a growing practice area for occupational medicine, occupational social work, industrial psychology and other occupational health professions. traumatic workplace events vary greatly in their level of org...

Blood-brain barrier (BBB) disruption is a common feature of numerous neurologic disorders. A fundamental question in these diseases is the extent inflammatory immune cells contribute to CNS vascular permeability. We have previously shown that CD8 T cells play a critical role in initiating BBB disruption in the peptide-induced fatal syndrome model developed by our laboratory. However, myelomonoc...

This study investigated the effects of streptozotocin-induced diabetes on the functional integrity of the blood-brain barrier in the rat at 7, 28, 56, and 90 days, using vascular space markers ranging in size from 342 to 65,000 Da. We also examined the effect of insulin treatment of diabetes on the formation and progression of cerebral microvascular damage and determined whether observed functi...

The disruption of operations due to IS failure becomes more important as IS has become an increasingly essential component of the organization’s operations and can affect its strategic objectives. Nevertheless, traditional IS risk analysis methods do not adequately reflect the loss from disruption of operations in determining the value of IS assets. Quantitative methods do not measure the loss ...

Purpose This paper aims to examine the relationship of supply chain disruption risk drivers performance and firm outcomes. Design/methodology/approach Four for a are identified, namely, demand risk, process environment risk. A cross-sectional survey was developed data collected from 315 Chinese firms determine risks performance. Findings The empirical findings show that have significant impact ...

Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified. Here we report the first step in such an endeavor for prostate cancer. We provide a comprehensive annotation of the 77 known risk loci, based upon highly correlated variants in biologicall...

Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep...

Juvenile offenders face a broad array of adverse risk factors, ranging from family disruption to negative peer influence. As the number of these risk factors increase, so does the probability of a youth’s subsequent involvement in delinquency. Accordingly, we should not be surprised that those youth who are at greatest risk of becoming serious, violent, and chronic offenders are often involved ...

Agricultural supply chain (ASC) plays a vital role for sustainability as it is the main source of food supply. ASC encounters more sources risk due to seasonality, perishability, and weather conditions, which makes global security system complex. This paper develops an optimization model perishable product decide optimal management strategy that maximizes decision maker's expected profit under ...

This paper proposes a bi-objective reliable supply chain network design that immunizes the network against different sources of uncertainties. In this regard, scenario based stochastic programming method is applied to model different disruption scenarios affecting accurate performance of network stages. Also, reliable and unreliable facilities are suggested for lessening vulnerability of networ...