UNLABELLED Auditory processing and phonemic discrimination are essential for communication. TYPE OF STUDY Retrospective. AIM To evaluate auditory processing and phonemic discrimination in children with normal and disordered phonological development. MATERIAL AND METHODS An evaluation of 46 children was carried out: 22 had phonological disorders and 24 had normally developing speech. Dioti...

An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outside, and intermediate states are observed in their binding processes. We consider that stepwise target recognition via intermediate states is a chara...

This study aims to systematically review original articles investigating the link between spectral acoustic measures in healthy talkers and perceived speech intelligibility, according PRISMA guidelines. Twenty-two studies were retained. Eighteen papers investigated vowel acoustics, one studied glides eight consonants, mostly sibilants. Various intelligibility estimates used. The following shown...

Children with developmental disabilities such as childhood apraxia of speech (CAS) require repeated intervention sessions with a speech therapist, sometimes extending over several years. Technology-based therapy tools offer the potential to reduce the demanding workload of speech therapists as well as time and cost for families. In response to this need, we have developed “Tabby Talks,” a multi...

Multiple reports have described patients with disordered articulation and prosody, often following acute aphasia, dysarthria, or apraxia of speech, which results in the perception by listeners of a foreign-like accent. These features led to the term foreign accent syndrome (FAS), a speech disorder with perceptual features that suggest an indistinct, non-native speaking accent. Also correctly kn...

BACKGROUND Changes to spoken communication are inevitable in Parkinson's disease (PD). It remains unclear what consequences changes have for intelligibility of speech. AIMS To establish the prevalence of impaired speech intelligibility in people with PD and the relationship of intelligibility decline to indicators of disease progression. METHODS 125 speakers with PD and age matched unaffect...