Riassunto: Si propone un modello gerarchico Bayesiano a due stadi per l’analisi geografica del rischio relativo di malattia. Al primo livello si assume che il numero osservato di casi della malattia d’interesse si distribuisca in accordo a una distribuzione di Poisson, con valore atteso il prodotto tra il rischio relativo specifico per area e il numero atteso di casi sotto ipotesi di omogeneità...

This is a somewhat curious little book which was intended to be a concise note-book for medical, dental and other students to give them a brief idea of the subject before they attend their lectures and practical classes. It is no doubt a novel and ingenious idea on which the author may be congratulated. Blank pages have been put in so that students may draw diagrams from what they actually see ...

Alzheimer's disease (AD) is the most common neurodegenerative disorder to date. Neuropathological hallmarks are β-amyloid (Aβ) plaques and neurofibrillary tangles, but the inflammatory process has a fundamental role in the pathogenesis of AD. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes, the complement system, as well as cytokines ...

The clinical, pathological, and immunological similarities between Kawasaki disease and the staphylococcal and streptococcal toxic shock syndromes suggest that a superantigen toxin may be involved in the pathogenesis of the disease. The V beta repertoire of peripheral blood mononuclear cells from 21 children with Kawasaki disease, 28 children with other illnesses, and 22 healthy controls were e...

BACKGROUND/AIM conventional teaching on integrated care pathways (ICP) suggests that they have to be specific both to a particular setting and to a specific diagnosis. We wished to explore the potential for a generic process-based care pathway. STUDY DESIGN we evaluated three different, disease-specific ICPs in use on a neurological rehabilitation unit to identify prompts common to and differ...

Handicap is the result of a process of disablement whose origin is a pathological condition (disease). According to some definitions of health (e.g., a state of complete physical, mental and social well-being), the classical biomedical concept is too restrictive to cover all the consequences of disease. New models have been proposed: the impairment-disability-handicap model presented by WHO, th...

in Florence showed some symptomatic improvement with only minor side effects, but this requires confirmation in a controlled trial. Cyclosporin A does not cause bone marrow depression; but reports of the development of lymphoma in patients treated with the drug after transplantation,6 and indeed in patients treated with other immunosuppressive drugs,7 mean that immunosuppression should be used ...

The formation of a new joint between a pathologically elongated coronoid process and the body of the malar homolateral bone is known as Jacob's disease. Coronoid process hyperplasia was first described in 1853 by Von Langenbeck, and it was not until 1899 when Oscar Jacob described the disease that it was named after him. Jacobs's disease is an uncommon entity with only a few documented cases in...

BACKGROUND Several in vitro studies have suggested levodopa (L-dopa) to be toxic to dopaminergic neurons and that it can modulate the aggregation process of α-synuclein. We investigated the relationship between cumulative lifetime dose of l-dopa and nigral neuronal count and Lewy body (LB) pathology in Parkinson disease (PD). METHODS Density of pigmented neurons was measured unilaterally in a...

The emergence and re-emergence of various viral diseases indicate the need for the development of effective and authentic new diagnostic methods. The diagnostic application of gel-based PCR, general PCR systems, phylogeny, molecular epidemiology, real-time PCR, amplification without thermo-cycling, multiplex PCR, nucleic acid extraction and pipetting robotics, automation and quality control, in...