The relationship of the neurological manifestations to the lupus disease process is not always clear. We present a case of systemic lupus erythematosus (SLE) with subacute onset muscle weakness, which was due to polyradiculopathy, a rarely described neurological manifestation of SLE.

ALTHOUGH ocular lesions are known to occur in acute systemic lupus erythematosus, the only report in Great Britain of the histological examinationi of the eyes in this disease appears to be that of Semon and Wolff (1933), who found only mild choroiditis and subretinal exudation. The purpose of this paper is to record the clinical, ophthalmoscopic, and pathological findings in two cases which te...

The simultaneous occurrence of a thymoma and systemic lupus erythematosus (SLE) is reported. Disease state associated with thymoma are reviewed and the possible immunological basis for this spectrum of diseases is discussed. The role of angiography in the diagnosis of thymic tumours is described.

IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-pr...

Cutaneous involvement is a prominent feature in connective tissue disease and the skin lesions are extremely important in diagnosing and subclassifying patients with these conditions. Fifty cases of connective tissue diseases of skin were studied over a period of two years to analyze overlapping of histopathological features, possible transformation of one disease to the other and co-existing c...

Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus erythematosus. It tends to heal with scarring, hair loss, and pigmentary changes if treatment is not initiated in the early phase of the disease. Classic DLE lesions are initially red-purple macules, papules, or small plaques that rapidly acquire a hyperkeratotic appearance. Only a minority of patients with DLE...

Drug-induced lupus erythematosus (DILE) refers to a condition whose clinical, histological, and immunological features are similar to those seen in idiopathic lupus erythematosus but that occurs when certain drugs are taken and resolves after their withdrawal. Over 90 drugs have been linked to DILE to date and the list is growing. Like idiopathic lupus erythematosus, DILE has systemic, subacute...