BACKGROUND The inability of aspirin (acetylsalicylic acid [ASA]) to adequately suppress platelet function is associated with future risk of myocardial infarction, stroke, and cardiovascular death. Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness. METHODS AND RESULTS We examined platelet ASA responsiveness in 1880 asymptomatic subjects (mean age, 44+/-...

Ecological stoichiometry and resource competition theory both predict that nutrient rates and ratios can alter infectious disease dynamics. Pathogens such as viruses hijack nutrient rich host metabolites to complete multiple steps of their epidemiological cycle. As the synthesis of these molecules requires nitrogen (N) and phosphorus (P), environmental supply rates, and ratios of N and P to hos...

BACKGROUND Metastasis to regional lymph nodes via lymphatic vessels plays a key role in cancer progression. Tumor lymphangiogenesis is known to promote lymphatic metastasis, and vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis during the process of metastasis. We previously identified periostin as an invasion- and angiogenesis-promoting factor in ...

pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...

changes in groundwater quality, is caused destruction of other resources, either directly or indirectly, due to bad management of groundwater extractions. considering the importance of groundwater resources, especially in arid and semiarid regions, this research was done to modeling the spatial distribution of some groundwater qualitative factors with emphasis on drinking using geostatistical m...

escherichia coli o157:h7 is found in cattle farms and can live in the intestine of healthy cattle. mostcases of human illnesses including nonbloody diarrhea, hemorrhagic colitis and hemolytic uremic syndromecan be traced, either directly or indirectly, to cattle. one strategy for reducing the risk of enterohemorrhagicescherichia coli (ehec) infections in human is to reduce the prevalence of inf...

Research identifying similar and dissimilar risk factors for directly and indirectly selfinjurious behaviours among adolescents is scarce. Due to the wide range of physical and mental health difficulties that may result from self-injurious behaviours, understanding differential risks is important to support at-risk adolescents. To address this gap in the literature, 541 clinically referred chil...

Investigations into the cellular processing of radiolabeled monoclonal antibodies (mAbs) for their further use in radioimmunodiagnosis and cancer therapy are needed in order to understand the fate of internalized and catabolized mAbs. The anti-colorectal cancer mAb, A33, was labelled with 76Br and 125I using the direct Chloramine-T method, or by labelling N-succinimidyl para-(tri-methylstannyl)...

In chemotaxis of Escherichia coli and other bacteria, extracellular stimuli are perceived by transmembrane receptors that bind their ligands either directly, or indirectly through periplasmic-binding proteins (BPs). As BPs are also involved in ligand uptake, they provide a link between chemotaxis and nutrient utilization by cells. However, signalling by indirectly binding ligands remains much l...