Respiration-linked contraction of corn mitochondria is not noticeably reduced by low, uncoupling concentr*tions of dinitrophenol. However, if a oontraction/respiration ratio is calculated, the contraction proves to be uncoupled. Previous statements that contraction cannot be uncoupled from respiration are in error. The uncoupling of c-ontraction is oonsistent with the concept that dinitrophenol...

A new series of 2-amino-5-arylazothiazole derivatives has been designed and synthesized in 61-78% yields and screened as potential antibacterial drug candidates against the Gram negative bacterium Escherichia coli. The geometry of the title compounds were being studied using the Material Studio package and semi-core pseudopods calculations (dspp) were performed with the double numerica basis se...

tween oxygen consumption and phosphate absorption. New Phytologist 55: 1-28. 1956. 13. JUDAH, J. D. and WILLIAMs-ASHMAN, H. G. The inhibition of oxidative phosphorylation. Biochem. Jour. 48: 33-42. 1951. 14. KRAHL, M. E. and CLOWES, G. H. A. Studies on cell metabolism and ceil division. II. Stimulation of cellular oxidation and reversible inhibition of cell division by dihalo and trihalophenols...

The toxicities of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats was examined and the susceptibility of newborn rats was analyzed in terms of presumed unequivocally toxic and no observed adverse effect levels (NOAELs). In the 18-day repeated dose newborn rat study, 4-nitrophenol was orally given from Day 4 to Day 21 after birth but did not induce any toxicity up to 160 mg/kg in t...

Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty...

5. Anaerobic incubation caused an inhibition of synthesis only in the presence of oxaloacetate; no inhibition was observed anaerobically in the presence of a-oxoglutarate plus malonate. 6. Hg2+ and arsenate almost completely abolished fatty acid synthesis; cyanide and 2:4-dinitrophenol caused a moderate (30-70%) inhibition, while azide and fluoride were without effect. 7. The implication of the...

EmrR, the repressor of the emrRAB operon of Escherichia coli, was purified to 95% homogeneity. EmrR was found to bind putative ligands of the EmrAB pump-2,4-dinitrophenol, carbonyl cyanide m-chlorophenylhydrazone, and carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone-with affinities in the micromolar range. Equilibrium dialysis experiments suggested one bound ligand per monomer of the dimer...

MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affe...