ALTERED MORPHOLOGY AND COMPOSITION OF ZYMOGEN GRANULES INACUTE PANCREATITISby AMANDA FLACKAugust 2014Advisor: Dr. Bhanu JenaMajor: PhysiologyDegree: Doctor of PhilosophyIn healthy physiology, pancreatic digestive enzymes secreted following a meal are storedas inactive zymogens within membrane-bound secretory vesicles called Zymogen Granules(ZG), and activ...

The Hessian fly, Mayetiola destructor, is a serious pest of wheat and an experimental organism for the study of gall midge-plant interactions. In addition to food digestion and detoxification, the gut of Hessian fly larvae is also an important interface for insect-host interactions. Analysis of the genes expressed in the Hessian fly larval gut will enhance our understanding of the overall gut p...

Intracellular activation of pancreatic digestive enzymes by lysosomal hydrolases is thought to be an early event in the pathogenesis of pancreatic injury. As ethanol excess is an important association of pancreatitis, experimental work has been directed towards exploring possible mechanisms whereby ethanol may facilitate contact between inactive digestive enzyme precursors and lysosomal enzymes...