Co-occurrence of neurodegenerative proteinopathies is increasingly recognized to be a frequent event in the brains of symptomatic and asymptomatic elderly individuals [1]. Prion diseases are rapidly progressive neurodegenerative conditions, which may pose differential diagnostic challenges. Co-occurence of diverse pathologies in prion disease is rarely reported, although occasionally unusual co...

in this article differential transformation method (dtms) has been used to solve neutral functional-differential equations with proportional delays. the method can simply be applied to many linear and nonlinear problems and is capable of reducing the size of computational work while still providing the series solution with fast convergence rate. exact solutions can also be obtained from the kno...

Partial differential equations are used to describe physical phenomena in many science and engineering fields. Finite differencing methods map these continuous equations into discrete space so that they may be solved on computers. Co-Array Fortran provides the means for implementing such solution methods in parallel processing computing environments. In this report we describe our experiences w...

MOTIVATION Standard analysis routines for microarray data aim at differentially expressed genes. In this paper, we address the complementary problem of detecting sets of differentially co-expressed genes in two phenotypically distinct sets of expression profiles. RESULTS We introduce a score for differential co-expression and suggest a computationally efficient algorithm for finding high scor...

in this paper, we study the numerical solution of hybrid fuzzy differential equations by using differential transformation method (dtm). this is powerful method which consider the approximate solution of a nonlinear equation as an infinite series usually converging to the accurate solution. several numerical examples are given and by comparing the numerical results obtained from dtm  and  predi...

A 13 year old girl presented with auricular chondritis and recurrent episodes of unexplained chest pain, arthritis, bronchitis, conjunctivitis, prolonged steroid resistant alopecia areata, and a history of recurrent tonsillitis. Both the mosaic of autoimmunity and relapsing polychondritis were considered in the differential diagnosis. The patient was successfully treated with co-trimoxazole. Th...

The present investigation deals with formulation of nicotinamide-based co-crystals of fenofibrate by different methods and solid-state characterization of the prepared co-crystals. Fenofibrate and nicotinamide as a coformer in 1:1 molar ratio were used to formulate molecular complexes by kneading, solution crystallization, antisolvent addition and solvent drop grinding methods. The prepared mol...

Pheophorbide a was prepared from a mixture o f chlorophylls a and b by differential extrac­ tion with HC1 and saponification. The insertion o f the following metal ions was investigated: Mg, Zn, Co, Cu, Ni. In the enzyme test with chlorophyll synthetase, the metallopheophorbides fall into two categories: the Mgand Zn-complexes are good substrates, the Co-, Cuand Ni-complexes are neither substra...

This article reports experimental data related to the research article entitled "Poly(malic acid-co-l-lactide) as a Superb Degradation Accelerator for Poly(l-lactic acid) at Physiological Conditions" (H.T. Oyama, D. Tanishima, S. Maekawa, 2016) [1]. Hydrolytic degradation of poly(l-lactic acid) (PLLA) blends with poly(aspartic acid-co-l-lactide) (PAL) and poly(malic acid-co-l-lactide) (PML) oli...

Co-expression analysis reveals useful dysregulation patterns of gene cooperativeness for understanding cancer biology and identifying new targets for treatment. We developed a structural strategy to identify co-expressed gene networks that are important for chronic myelogenous leukemia (CML). This strategy compared the distributions of expressional correlations between CML and normal states, an...