Predictive cardiac electrophysiology models can provide a substantial aid in the success of the treatment of cardiac arrhythmias. Sufficiently accurate model predictions highly depend on the personalisation of the model i.e. estimation of patient-specific model parameters. In this paper, we evaluate the prediction ability of a simplified ionic 3D cardiac electrophysiology model, the Mitchell-Sc...

The mechanisms underlying neuronal death following excessive activity such as occurs during prolonged seizures are unclear, but mitochondrial dysfunction has been hypothesised to play a role. Here, we tested this with fluorescence imaging techniques in rat glio-neuronal neocortical co-cultures using low Mg(2+) levels to induce seizure-like activity. Glutamate activation of NMDA receptors result...

Clayey soils are the most common material used for water sealing and undertake an important role in controlling landfill-related pollution. Organic liquids can adversely affect the effectiveness of clay liners by drastically increasing their hydraulic conductivity. The aim of this study is to investigate and compare the permeability in two types of clay with different plasticity, exposed to the...

We present the results from the analysis of 26 extragalactic radio sources of type FRII which were observed with the VLA at 5 GHz and around the 1.4 GHz band. The sources were selected to have redshifts in the range 0.3 < z < 1.3, radio powers between 6.9×10WHz < P151MHz < 1.3×10 WHz and angular size θ ≥ 10. We found that the depolarisation and the rms variations in the rotation measure increas...

Mechanisms underlying pacemaker activity in the sinus node remain controversial, with some ascribing a dominant role to timing events in the surface membrane ("membrane clock") and others to uptake and release of calcium from the sarcoplasmic reticulum (SR) ("calcium clock"). Here we discuss recent evidence on mechanisms underlying pacemaker activity with a particular emphasis on the many roles...

In this work, we investigated the stability of Molybdate-Phosphonic Acid (MPA) complex by density functionaltheory (DFT) computations in six solvents with the dielectric constant ranging from 1.92 to 10.36. The methodsare used for calculations are B3LYP and B3PW9 I that have been studied in two series of basis sets: D95nand6-31+G (d,p) for hydrogen and oxygen atoms; LANL2DZ for Mo and Phosphoru...

The dielectric susceptibility and dielectric tunability of the temperature-graded BaTiO3 thin films are investigated by using a modified transverse Ising model, taking the four-spin interaction and quantum fluctuation into account. There is a broad and smooth peak of the dielectric susceptibility at low temperature except for the sharp dielectric peak corresponding to the phase-transition tempe...

New sequence data resources allow the investigation of physiologically important processes in spotlight evolution to an unprecedented level detail. Outward-rectifying Kout channels and TPC1 – cation predominantly involved electrical signalling angiosperms have remained largely conserved during land plant evolution. Inward-rectifying potassium segregated into different subclades seed plants, aft...