نتایج جستجو برای: diazoxide
تعداد نتایج: 1114 فیلتر نتایج به سال:
Hyperinsulinemic hypoglycemia (HH) is the most common cause of persistent hypoglycemia in infants. The first choice of medical treatment for HH is diazoxide, sodium and fluid retention being commonly associated its side effects. Other cardiovascular and hematological adverse effects have also been reported. Presented herein is case of a preterm infant (gestational age: 31 weeks) with HH who dev...
Objective: The aim of this study was to test the safety of diazoxide and to search for signs of efficacy in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: In this multicenter, randomized, placebo-controlled, double-blind trial (treatment allocation was concealed), 102 patients with RRMS were randomized to receive a daily oral dose of diazoxide (0.3 and 4 mg/d) or placebo ...
Two sibs who sustained severe hypoglycaemia in the neonatal period are reported. In spite of treatment with frequent feeds intravenous glucose, glucagon, hydrocortisone, and diazoxide, hypoglycaemia persisted, and both infants eventually required subtotal pancreatectomy. Tests for leucine toleranct were normal though the second case showed some protein sensitivity. Histological and immunohistoc...
Ischemic preconditioning, a phenomenon in which brief episodes of ischemia and reperfusion paradoxically protect the heart against subsequent lethal ischemia,1 has been conceptually divided into triggers and mediators/effectors.2,3 The trigger, which acts before the index ischemia, is followed by the protection of mediators/effectors during the lethal ischemia. Known triggers include activation...
Discussion The administration of diazoxide to this patient has resulted in haemolysis on three occasions. On the first two of these, the fall in haemoglobin was of the order of 5-6 g over a time interval of about 6 weeks, and on the third 3-8 g in 2 weeks. In episode 2 the diazoxide was continued, and the haemoglobin was maintained at about 10 g in spite of this. Recovery followed the cessation...
A new-born baby with Beckwith's syndrome had severe hypoglycaemia, and was treated with glucagon and prednisone. Treatment was stopped at 1 month of age and his blood glucose levels were satisfactory for the ensuing 6 weeks. However, at 10 weeks of age, he had a hypoglycaemic convulsion and required large doses of diazoxide and prednisone for the next 2 months to maintain the blood glucose abov...
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