results during the 3 months study, in the placebo group, systolic bp (sbp) increased with 6.3 mmhg and diastolic bp (dbp) increased with 4.6 mmhg, changes which were significant. after the 3 months, the effect of garlic on sbp, after adjusting for baseline value, was significant, and this effect was more significant in hypertensive patients. plasma lipids and lipoproteins did not change signific...

The aim. To study the impact of COVID-19 upon intracardiac hemodynamics and heart rate variability (HRV) in stable coronary artery disease (SCAD) patients.
 Materials methods. In this cross-sectional we analyzed clinical instrumental data obtained from a sample 80 patients. patients were divided into three groups: group 1 included with SCAD without (n=30), 2 (n=25), 3 (n=25). control 30 re...

OBJECTIVES This study determined whether there is development of tachyphylaxis to enhancement of cardiorenal response to acute volume loading (AVL) with B-type natriuretic peptide (BNP) after 12-week, twice-daily subcutaneous BNP administration in patients with preclinical diastolic dysfunction (PDD). BACKGROUND PDD is characterized by normal systolic function and moderate or severe diastolic...

OBJECTIVES To investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later. DESIGN Cohort study. SETTING Two areas (Southall and Brent) of northwest London. PARTICIPANTS Survey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years lat...

OBJECTIVES To assess cognitive impairment after off-pump coronary-artery bypass grafting, with a particular emphasis on long-term follow-up and related risk factors. DESIGN Prospective study. SETTING Virgen de la Victoria University Hospital, Málaga, Spain. PARTICIPANTS Participants were 36 patients undergoing off-pump coronary-artery bypass grafting. MEASUREMENTS Changes in the neurops...

This study was designed to examine the effects of the antioxidant resveratrol on cardiac structure and function in pressure overload (PO)-induced cardiac hypertrophy. Male Sprague-Dawley rats were subjected to sham operation and the aortic banding procedure. A subgroup of sham control and aortic-banded rats were treated with resveratrol for 2 wk after surgery. Echocardiographic analysis of card...

AIMS Hypertrophic cardiomyopathy (HCM) is the commonest cause of sudden cardiac death in the young, with an excess of exercise-related deaths. The HCM sarcomere mutations increase the energy cost of contraction and impaired resting cardiac energetics has been documented by measurement of phosphocreatine/ATP (PCr/ATP) using (31)Phosphorus MR Spectroscopy ((31)P MRS). We hypothesized that cardiac...

BACKGROUND Ventricular hypertrophy is a physiological response to pressure overload that, if left untreated, can ultimately result in ventricular dysfunction, including diastolic dysfunction. The aim of this study was to test the hypothesis that frequency-dependent myofilament desensitization, a physiological response of healthy myocardium, is altered in hypertrophied myocardium. METHODS AND ...

OBJECTIVE Decay kinetics of the voltage-gated L-type Ca(2+) current (I(CaL)) control the magnitude of Ca(2+) influx during the cardiac action potential. We investigated the influence of changes in diastolic membrane potential on I(CaL) decay kinetics in cardiac cells. METHODS Cells were isolated enzymatically from rat ventricles, human right atrial appendages obtained during corrective heart ...