نتایج جستجو برای: dialysis related amyloidosis

تعداد نتایج: 1210016  

Journal: :Annals of the rheumatic diseases 1990
P Netter M Kessler A Gaucher B Bannwarth

Annals of the RHEUMATIC DISEASES Leader Does aluminium have a pathogenic role in dialysis associated arthropathy? Dialysis has improved the prognosis and quality of life for patients with chronic renal insufficiency, but at the price of various complications. The first to be recognised were the acute myoclonic encephalopathies,' 2 whose main cause is aluminium overload. This overload results fr...

Journal: :JACC. Cardiovascular imaging 2014
Eloisa Arbustini Giampaolo Merlini

Amyloidosis is characterized by the extracellular deposition of highly-organized fibrillar aggregates showing a cross-beta super-secondary structure (1). Several proteins are amyloidogenic in humans, resulting in different clinical presentations, either systemic or localized. Transthyretin-related hereditary amyloidosis (ATTR) is a late-onset, dominantly inherited systemic amyloidosis. Heterozy...

2015
Agnese Milandri Simone Longhi Christian Gagliardi Mario Cinelli Serena Foffi Ilaria Bartolomei Fabrizio Salvi Claudio Rapezzi

Background Carpal tunnel syndrome (CTS) is one of the most common clinical manifestations of TTR-related amyloidosis, both hereditary (ATTR), and wild type (senile systemic amyloidosis, SSA) and often precedes cardiac symptoms. The exact prevalence of CTS in light-chain amyloidosis (AL), ATTR and SSA is not known. We therefore aimed to establish prevalence, risk factors and possible association...

Journal: :Circulation 2014
Candida Cristina Quarta Scott D Solomon Imran Uraizee Jenna Kruger Simone Longhi Marinella Ferlito Christian Gagliardi Agnese Milandri Claudio Rapezzi Rodney H Falk

BACKGROUND Immunoglobulin amyloid light-chain (AL)-related cardiac amyloidosis (CA) has a worse prognosis than either wild-type (ATTRwt) or mutant (ATTRm) transthyretin (TTR) CA. Detailed echocardiographic studies have been performed in AL amyloidosis but not in TTR amyloidosis and might give insight into this difference. We assessed cardiac structure and function and outcome in a large populat...

Journal: :Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2012
Bradley A Warady Sevcan Bakkaloglu Jason Newland Michelle Cantwell Enrico Verrina Alicia Neu Vimal Chadha Hui-Kim Yap Franz Schaefer

Division of Pediatric Nephrology,1 Children’s Mercy Hospitals and Clinics, Kansas City, Missouri, USA; Gazi University,2 Ankara, Turkey; Great Ormond Street Hospital,3 London, England; G. Gaslini Children’s Hospital,4 Genoa, Italy; Johns Hopkins University School of Medicine,5 Baltimore, Maryland, USA; National University of Singapore,6 Singapore; and University Children’s Hospital,7 Heidelberg...

2014
Rachelle Y. Leong Kusuma Nio Lauren Plumley Ernesto Molmenti Jonathan D.S. Klein

There are two major forms of amyloidosis, primary amyloidosis (AL) and secondary amyloidosis. AL amyloidosis results from deposition of immunoglobulin light chains or their fragments. One such example is AL amyloidosis associated with multiple myeloma, in which overproduced immunoglobulin light chains get deposited onto tissues, leading to tissue dysfunction. Amyloidosis in the intestines can p...

Journal: :The Eurasian journal of medicine 2010
Mustafa Keles Nilnur Eyerci Abdullah Uyanik Bulent Aydinli Gonul Zisan Sahin Ramazan Cetinkaya Ibrahim Pirim Kamil Yalcin Polat

OBJECTIVE Our goal is to investigate the distribution of MEFV mutations in patients with renal amyloidosis who are in renal transplant waiting list which is prepared for transplantation. MATERIALS AND METHODS FMF was diagnosed in 25 of the 297 patients between the years 2004 and 2008, who were involved in the study (15 male, 10 female; age 34±7.8). 5 out of 25 patients were transplanted, rema...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Tatsuya Ikenoue Young-Ho Lee József Kardos Hisashi Yagi Takahisa Ikegami Hironobu Naiki Yuji Goto

Amyloid fibrils form in supersaturated solutions via a nucleation and growth mechanism. Although the structural features of amyloid fibrils have become increasingly clearer, knowledge on the thermodynamics of fibrillation is limited. Furthermore, protein aggregation is not a target of calorimetry, one of the most powerful approaches used to study proteins. Here, with β2-microglobulin, a protein...

2011
Timo Eichner Sheena E Radford

Several protein misfolding diseases are associated with the conversion of native proteins into ordered protein aggregates known as amyloid. Studies of amyloid assemblies have indicated that non-native proteins are responsible for initiating aggregation in vitro and in vivo. Despite the importance of these species for understanding amyloid disease, the structural and dynamic features of amyloido...

Journal: :Clinical Journal of the American Society of Nephrology 2008

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