background: over the last 10 years, the evidential practice has been developing in kazakhstan. the clinical protocols of diagnostics and treatment were implemented in the country since 2007. we analyzed the normal birth practice in kazakhstan. materials and methods: obstetricians and midwives were subject to the questionnaire survey in four large maternity hospitals of almaty. results: totally,...

Introduction A Clinical Pathway (CP) is a multidisciplinary plan of care based on best clinical practice for a specified group of patients with a particular diagnosis. A CP is designed to minimize delays, optimize resource utilization, and maximize quality of care. CPs support the implementation of Casemix by reducing variations of care, increasing homogeneity of cases, improving quality of Cas...

BACKGROUND The adoption in oncology of Clinical Decision Support (CDS) may help clinical users to efficiently deal with the high complexity of the domain, lead to improved patient outcomes, and reduce the current knowledge gap between clinical research and practice. While significant effort has been invested in the implementation of CDS, the uptake in the clinic has been limited. The barriers t...

The quantitative assessment of the change of gait symmetry has played a very important role in the clinical diagnostics. This paper investigated the application of an advanced hybrid machine learning approach such as the combining kernel-based principal component analysis (KPCA) with support vector machine (SVM) to evaluate the change of gait symmetry quantitatively based on the basic idea that...

Despite the routine nature of comparing sequence variations identified during clinical testing to database records, few databases meet quality requirements for clinical diagnostics. To address this issue, The Royal College of Pathologists of Australasia (RCPA) in collaboration with the Human Genetics Society of Australasia (HGSA), and the Human Variome Project (HVP) is developing standards for ...

Aptamers are artificial oligonucleotides (DNA or RNA) selected in vitro that bind a broad range of targets with high affinity and specificity; a sensitive yet simple method to utilize aptamers as recognition elements for the development of biosensors (aptasensors) is to transduce the signal electrochemically. So far, aptasensors have been applied to clinical diagnostics and several technologies...