نتایج جستجو برای: diabetic nephropathies
تعداد نتایج: 111533 فیلتر نتایج به سال:
M ost kidney diseases lead to progressive deterioration of renal function, but the rate of progression differs among different disease types and even among individual patients with the same disease. Experimental studies and clinical research over the last few decades have identified several plausible mechanisms for progression of renal disease in various animal models and in human disease. Thes...
Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and frequently progress to proteinuria and CKD or ESRD during long-term follow-up. Nonetheless, the exact molecular mechanisms by which these mutations exert their deleterious eff...
In our study we want to reveal the role of dental foci, compared to other localized infections, in the evolution of glomerular nephropathies. Therefore we followed up the link between the presence of these foci and the flare-up of glomerular nephropathies, with or without renal failure. A number of 328 patients with glomerulonephritis, primary or secondary, hospitalized in the Nephrology Depart...
It is estimated that over 10% of the adult population in developed countries have some degree of chronic kidney disease (CKD). CKD is a progressive and irreversible deterioration of the renal excretory function that results in implementation of renal replacement therapy in the form of dialysis or renal transplant, which may also lead to death. CKD poses a growing problem to society as the incid...
Heavy proteinuria is a major determinant of progression to ESRD for patients with chronic nephropathies and reducing proteinuria should be a key target for renoprotective therapy. In the Remission Clinic, we applied a multimodal intervention to target urinary proteins in 56 consecutive patients who had >3 g proteinuria/d despite angiotensin-converting enzyme inhibitor therapy. We compared the r...
There have been several global epidemics of chronic kidney disease of unknown etiology (CKDu). Some, such as Itai-Itai disease in Japan and Balkan endemic nephropathy, have been explained, whereas the etiology of others remains unclear. In countries such as Sri Lanka, El Salvador, Nicaragua, and India, CKDu is a major public health problem and causes significant morbidity and mortality. Despite...
Transcriptome analysis by RNA-seq technology allows novel insights into gene expression and regulatory networks in health and disease. To better understand the molecular basis of renal fibrosis, we performed RNA-seq analysis in the Unilateral Ureteric Obstruction (UUO) mouse model. We analysed sham operated, 2- and 8-day post-ligation renal tissues. Thousands of genes with statistical significa...
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