The purpose of this study was to prepare polymeric microspheres containing Ketoprofen (KFN) by single emulsion [oil-in-water (o/w)] solvent evaporation method. Polycaprolactone (PCL), biocompatible polymer, was used for the preparation of sustained released microspheres of KFN. A Plackett–Burman design was employed by using the Design-Expert® software (Version9.0.3.1, Stat-Ease Inc., Minneapoli...

The aim of this study was to prepare docetaxel-loaded chitosan microspheres and to evaluate their in vitro and in vivo characteristics. Glutaraldehyde crosslinked microspheres were prepared using a water-in-oil emulsification method, and characterized in terms of the morphological examination, particle size distribution, encapsulation ratio, drug-loading coefficient and in vitro release. Pharma...

This study focuses on the use of bio-nanocomposite microspheres, consisting of carbonated hydroxyapatite (CHAp) nanospheres within a poly(L: -lactide) (PLLA) matrix, to produce tissue engineering (TE) scaffolds using a modified selective laser sintering (SLS) machine. PLLA microspheres and PLLA/CHAp nanocomposite microspheres were prepared by emulsion techniques. The resultant microspheres had ...

The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic gelation methods. Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of microspheres showed that microsp...

In this study, gelatin microspheres containing lactic acid were prepared by the polymerization technique using glutaraldehyde as the cross-linking agent. Dried microspheres were loaded by immersing them in an aqueous solution of lactic acid. In order to prepare microspheres with an appropriate drug release profile, the effect of time of cross-linking and the amount of cross-linking agent on the...

A new approach for attaining sustained release of protein is introduced, involving a pore-closing process of preformed porous PLGA microspheres. Highly porous biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were fabricated by a single water-in-oil emulsion solvent evaporation technique using Pluronic F127 as an extractable porogen. Recombinant human growth hormone (rhGH) was...

Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate complex. As intravenous dextran can cause severe, antibody-mediated dextran-induced ...

Nanofibrous hydrogel microspheres are formed by pH gelation of perylene diimide derivatives in emulsion droplets. These microspheres are freeze-dried and subsequently carbonized to produce discrete N-doped nanofibrous carbon microspheres. The carbon microspheres show high performance as electrode materials for supercapacitors.

in the long-term management of ulcerative colitis patients, repeat dosing maybe required. since 5-asa is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. the aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-asa deliver...

We have compared the splenic responses following immunization with the T cell-independent (TI)-2 antigen native dextran B512 and with a thymus-dependent (TD) protein-dextran conjugate. Interestingly, primary immunization with native dextran induced germinal center (GC) formation in the spleen to the same extent as the protein-dextran conjugate. The GC were antigen-specific as characterized by t...