Breast cancer patients are often at high risk of fragility fractures partly due to adjuvant endocrine therapy such as aromatase inhibitors and chemotherapy. Baseline dual energy X-ray absorptiometry (DEXA) scanning is recommended as a standard of care in identifying patients who are at risk so they can be commenced on bone protective therapy. NICE guideline 80 - "Early and locally advanced brea...

Background Breast cancer remains the most common diagnosed in women worldwide. Aromatase inhibitors (AI) are employed for hormone sensitive disease mainly postmenopausal women. AI related bone loss (AIBL) is a known complication; although data regarding natural history real-world, long-term outcomes and role of active therapy fracture prevention sparse. Objectives Our aim was to determine real-...

BACKGROUND Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using ...

Abstract Introduction In England and Wales, there are approximately 75,000 proximal femoral fractures per year. Bone protection is vital in these patients a key recommendation of NICE guidelines (CG124) for multidisciplinary approach hip fracture management. Method Data were collected retrospectively using clinical portal, admission records medication charts. The data inputted into the FRAX cal...

Abstract Introduction In England and Wales, there are approximately 75,000 proximal femoral fractures per year. Bone protection is vital in these patients a key recommendation of NICE guidelines (CG124) for multidisciplinary approach hip fracture management. Method Data were collected retrospectively using clinical portal, admission records medication charts. The data inputted into the FRAX cal...

Objective To identify the prevalence of lumbar scoliosis in breast cancer patients and to investigate the potential risk factors of lumbar scoliosis. Methods A retrospective chart review was performed in breast cancer patients aged more than 40 years who underwent dual energy X-ray absorptiometry (DEXA) scanning between January 2014 and December 2014. We divided the patients into control and ...

Aquaporins (AQPs) are water-specific membrane channel proteins that regulate water homeostasis for cells and organisms. AQP5 serves an important role in the maintenance of mucosal water homeostasis, and potentially contributes to mucosal edema and inflammation formation in chronic rhinosinusitis (CRS). The aim of the present study was to explore the expression pattern of AQP5 and the effect of ...

Objective: Corticosterone treatment in mice impairs mitochondrial function, decreases energy production the brain, and induces depressive-like behaviors. Creatine (Crt) is vital for homeostasis brain. Alpha-lipoic acid (ALA) improves function reduces oxidative stress. The aim was investigating effect of Crt ALA following dexamethasone (Dexa) induced depression model despair. Methods: Female (22...

BACKGROUND Socioeconomic deprivation is associated with inequalities in health care and outcomes. Despite concerns that the Quality and Outcomes Framework pay-for-performance scheme in the UK would exacerbate inequalities in primary care delivery, gaps closed over time. Local schemes were promoted as a means of improving clinical engagement by addressing local health priorities. We evaluated eq...