Background: Hypoactive sexual desire disorder is the most common sexual disorder among women, which interferes with their various functions. Activity of brain-behavioral and psychological distress systems are considered among factors affecting sexual function. Objectives: The present study aimed to compare women with hypoactive sexual desire and normal women in terms of brain-behavioral and ...

Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. This gradually disinhibits the turnover of other monoamines like dopamine and noradrenaline that are critical for sexual desire.