Engineering functional tissues of clinically relevant size (in mm-scale) in vitro is still a challenge tissue engineering due to low oxygen diffusion and lack vascularization. To address these limitations, perfusion bioreactor was used generate contractile engineered muscles 3 mm-thickness 8 mm-diameter. This study aimed upscale the process 50 mm diameter by combining murine skeletal myoblasts ...

BACKGROUND Overexpression of stromal cell-derived factor-1 in injured tissue leads to improved end-organ function. In this study, we quantify the local trophic effects of mesenchymal stem cell (MSC) stromal cell-derived factor-1 release on the effects of MSC engraftment in the myocardium after acute myocardial infarction. METHODS AND RESULTS Conditional cardiac myocyte CXCR4 (CM-CXCR4) null m...

Background—Overexpression of stromal cell-derived factor-1 in injured tissue leads to improved end-organ function. In this study, we quantify the local trophic effects of mesenchymal stem cell (MSC) stromal cell-derived factor-1 release on the effects of MSC engraftment in the myocardium after acute myocardial infarction. Methods and Results—Conditional cardiac myocyte CXCR4 (CM-CXCR4) null mic...

The cartilage is a connective tissue that, due to the strength of its extracellular matrix, allows the tissue to tolerate mechanical stress without undergoing permanent deformation. It is responsible for the support of soft tissues and due to its smooth surface and elasticity, gives the joints the ability to slip and bend. excessive weight, excessive activity, or trauma can all cause cartilage ...

INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt anal sphincter cause considerable morbidity. Non-invasive trauma therapies have been widely developed, including growth factors administered platelet-rich plasma (PRP) stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) limited factor. This study aimed assess PRP SVF effec...