The possibility that an infant’s diet may influence the later development of obesity or of atheroma gives this subject its interest and importance. The concept of the body’s depot fat as constituting an ‘organ’ is probably a useful one, but only so long as it does not lead to unwarranted simplification. For instance, samples of depot fat taken from the adipose tissue of a baby’s buttock tend to...

BACKGROUND Little is known about the comparative effectiveness of atypical antipsychotics in long-acting injection formulation. Due to the absence of head-to-head studies comparing olanzapine long-acting injection and risperidone long-acting injection, this study was intended to make exploratory, indirect, cross-study comparisons between the long-acting formulations of these two atypical antips...

In this paper, a capacitated vehicle routing problem is discussed which occurs in the context of glass waste collection. Supplies of several different product types (glass of different colors) are available at customer locations. The supplies have to be picked up at their locations and moved to a central depot at minimum cost. Different product types may be transported on the same vehicle, howe...

This paper focuses on the railway rolling stock circulation problem in rapid transit networks where the known demand and train schedule must be met by a given fleet. In rapid transit networks the frequencies are high and distances are relatively short. Although the distances are not very large, service times are high due to the large number of intermediate stops required to allow proper passeng...

A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans fatty acids (TFAs)/ saturated fatty acids (SFAs), elaidic acid as a biomarker of margarine intake was used to screen affected adipokines on ma...

OBJECTIVE To report a case of right posterior subcapsular cataract induced by 3-monthly depot luteinizing hormone-releasing hormone (LHRH) analogue therapy in a patient with early prostate cancer. CASE PRESENTATION A 52-year-old male with static myopia of several years' duration was given a 3-month depot LHRH analogue (goserelin 10.8 mg) as part of neoadjuvant treatment for early prostate can...

It has long been recognized that body fat distribution and regional adiposity play a major role in the control of metabolic homeostasis. However, the ability to study and compare the cell autonomous regulation and response of adipocytes from different fat depots has been hampered by the difficulty of inducing preadipocytes isolated from the visceral depot to differentiate into mature adipocytes...

This paper focuses on a modified Multi-Depot Unmanned Aerial Vehicle Routing Problem (MMDUAVRP). Comparing to classic multi-depot vehicle routing problem, our studied problem has no constraints restrict the depot where (UAV) departs and returns. work aims minimize number of UAVs total distance traveled by all UAVs. is mathematically formulated in this heuristic-assignment based hybrid large nei...

The Rental Fleet Scheduling Problem (RFSP) arises in vehicle rental operations that offer a wide variety of vehicle types to customers, and allow a rented vehicle to “migrate” to a setdown depot other than the pickup depot. When there is a shortage of vehicles of a particular type at a depot, vehicles may be relocated to that depot, or vehicles of similar types may be substituted. The RFSP invo...

This paper describes a polynomial transformation for a class of unit-demand vehicle routing problems, named node-balanced routing problems (BRP), where the number of nodes on each route is restricted to be in an interval such that the workload across the routes is balanced. The transformation is general in that it can be applied to single or multiple depot, homogeneous or heterogeneous fleet BR...