نتایج جستجو برای: dependent thalassemia major
تعداد نتایج: 1273294 فیلتر نتایج به سال:
BACKGROUND During the past decades, beta thalassemia major (TM) and beta thalassemia intermedia (TI) have transformed from a universally fatal disease at a young age into a chronic disease. This advancement is attributed to improved chelation therapy as well as enhanced management strategies, with focused attention on disease and treatment-related complications. OBJECTIVES To describe charact...
Understanding the Intricacies of Iron Overload Associated with β-Thalassemia: A Comprehensive Review
β-thalassemia, a congenital genetic hematological disorder characterized by the decrease or absence of β-globin chains, leads to in levels Hemoglobin A. The affected individuals can be categorized into two cohorts based on transfusion dependency: transfusion-dependent thalassemia (TDT) and non-transfusion-dependent (NTDT). Remarkably, despite primary pathology lying chain depletion, β-thalassem...
inroduction: heart failure (hf) is an important cause of morbidity and mortality in the cases of beta-thalassemia major. the purpose of this study was to estimate hf prevalence in these patients and to assess the survivability of those who were treated with intensive chelating therapy. design and methods: this cross sectional study included 72 beta-thalassemia major cases, the mean age at the...
introduction: there are limited reports about selenium status in major thalassemia patients. the aim of this study is evaluation of selenium status in patients with major thalassemia south east of iran with large sample size and wide range of age. this study compared selenium status with other sites of the world. methods: in this study 369 cases that had major thalassemia for more than 5 years ...
abstract objective thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. the objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. methods among 70 beta thalassemia patients, 50 were selected for chelating therapy usin...
Hb E/b thalassemia is the most common b thalassemia syndrome in Asia-Pacific due to a high prevalent of Hb E and b thalassemia genes. Management of this condition can be cumbersome due to its clinical heterogeneity and various disease severity ranging from severe end in which patients are transfusion dependent thalassemia (TD) similar to that of b thalassemia major (TM) to moderate and mild sev...
BACKGROUND Hemoglobinopathies are the most common inherited diseases in southern China. However, there have been only a few epidemiological studies of hemoglobinopathies in Guangdong province. MATERIALS AND METHODS Peripheral blood samples were collected from 15299 "healthy" unrelated subjects of dominantly ethnic Hakka in the Meizhou region, on which hemoglobin electrophoresis and routine bl...
The aim of the present study was to investigate the lipid pattern in Jordanian children with Beta-thalassemia major (ß-TM). Twenty six transfusion dependent ß-TM patients, 14 males and 12 females, (mean age 9 ± 5 years) that undergo periodical blood transfusion and desferioxame as a chelating agent, were studied. Twenty controls of matched age and gender were also included in the study. ß-thala...
background: major thalassemia is an autosomal recessive disease with complications, mortality and serious pathology. today, the life expectancy of patients with major thalassemia has increased along with therapeutic advances. therefore, they need lifelong care, and caring for them would incur many costs. being aware of the patients’ costs can be effective for controlling and managing the costs ...
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