13 ADDRESS FOR CORRESPONDENCE: 14 *Dr. David Romero. 15 Programa de Ingeniería Genómica, Centro de Ciencias Genómicas-UNAM. Apartado 16 Postal 565-A, 62210 Cuernavaca, Mor., México. Tel.: +52 (777) 3175867 or +52 (777) 17 3291691; Fax: +52 (777) 3175581; E-mail: [email protected] 18 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved...

The advent of modern mouse genetics has benefited many fields of diseased-based research over the past 20 years, none perhaps more profoundly than cardiac biology. Indeed, the heart is now arguably one of the easiest tissues to genetically manipulate, given the availability of an ever-growing tool chest of molecular reagents/ promoters and “facilitator” mouse lines. It is now possible to modify...

Background: Genetic analysis in mice has lead to find about maternal effect genes such as Filia. Filia knock out mice have a 50% decrease in fertility. Filia dysfunction causes disorders in pre-implantation development. Mutations in human Filia gene, cause FBHM (Familial Biparental Hydatidiform Mole) in women. Filia protein in mice is homologous to that of rat and human, so this idea has emerge...

Objective: The peak bone mass is recognized as an important determinant in the development of osteoporosis. We investigated associations between bone mineral density (BMD) and polymorphisms of the leptin receptor (LEPR) and estrogen receptor a (ERa) genes in young men. Design: BMD, anthropometric characteristics, and serum leptin concentrations were measured in young men and compared with regar...

Genomic data Genotypes for about 40,000 single nucleotide polymorphisms (SNP) now act as a third source of data for national genetic evaluations of dairy cattle, in addition to phenotypes and pedigrees that were the basis of selection for the previous 100 years. Rapid developments in genotyping tools have lowered the cost of obtaining this genomic data to just over $200 per animal. The Illumina...

Genomic evaluations using genotypes from the Illumina Bovine3K BeadChip (3K) became available in September 2010 and were made official in December 2010. The majority of 3K-genotyped animals have been Holstein females. Approximately 5% of male 3K genotypes and between 3.7 and 13.9%, depending on registry status, of female genotypes had sire conflicts. The chemistry used for the 3K is different f...