Critical flicker frequency (CFF) was measured for stimuli varying in chromaticity only and in luminance only for patients with multiple sclerosis (MS) and for matched normal controls. The two CFF measurements showed different underlying linear interdependencies for the two groups, consistent with a greater loss of temporal luminance function than of temporal chromatic function in MS patients. T...

Recent histopathology studies suggest the presence of meningeal inflammation in patients with multiple sclerosis (MS) that might be associated with subpial cortical demyelination and a rather worse disease course.1 Although a radiologist is not a pathologist, diagnostic neuroradiology aims to visualize and to detect almost every (subtle) pathological feature of a disease to its full extent. To ...

Whenever MRI imaging depicts typical small, ovoid, well-circumscribed T2 hyperintense lesions scattered across periventricular, iuxtacortical and infratentorial white matter along with a clinical scenario highly suggestive of inflammatory-demyelinating disease of CNS (CNS IID), multiple sclerosis (MS) diagnosis is straightforward. Nevertheless, the expanding role of MRI in MS evaluation is para...

Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell bi...

In 1961, Richard and Mary Bunge discovered and reported the phenomenon of spontaneous myelin repair using an animal model of demyelination [1]. Only four years later, the same possibility was observed in specimens from patients diagnosed with multiple sclerosis (MS), what would eventually be the starting point of a true scientific revolution – the demonstration that the human central nervous sy...

Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated and demyelinated tissue. The reason for concentric demyelination in this variant of multiple sclerosis is unclear. In the present study we investigated the immunopathology in autopsy tissue of 14 patients with acute multiple sclerosis or fulminant exacerbations of chronic multiple sclerosis with Baló-ty...

how to cite this article: inaloo s, haghbin s. multiple sclerosis in children. iran j child neurol. 2013 spring;7(2):1-10.   multiple sclerosis (ms) is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. a total of 4% to 5% of ms population are pediatric. pediatric ms is defined as the appearance of ms before the age of sixteen. about...

Whether or not recurrent tumefactive demyelinating lesions are a unique form of CNS demyelinating disease or part of the continuum of multiple sclerosis is a question raised by the case report on which this commentary is based. Detailed review and immunopathologic study of biopsy material may not only confirm or refute a diagnosis of demyelinating disease, but potentially uncover unique feature...

A psychophysical technique involving simple increment threshold measurements was used to determine foveal chromatic and luminance sensitivity in patients with multiple sclerosis (MS) and in matched normal controls. The patient group showed substantial and nonselective losses in chromatic and luminance sensitivity relative to the normal control group, and these losses were significantly correlat...