نتایج جستجو برای: deirdre shauna lynch
تعداد نتایج: 4046 فیلتر نتایج به سال:
LOUISE CHAVARIE, ANDREW M. MUIR, MARA S. ZIMMERMAN, SHAUNA M. BAILLIE, MICHAEL J. HANSEN, NANCY A. NATE, DANIEL L. YULE, TREVOR MIDDEL, PAUL BENTZEN and CHARLES C. KRUEGER Center for Systems Integration and Sustainability, Michigan State University, 115 Manly Miles Building, 1405 South Harrison Road, East Lansing, Michigan, USA Great Lakes Fishery Commission, 2100 Commonwealth Blvd., Suite 100,...
Assessing and addressing ongoing information and support needs among individuals with Lynch syndrome
Background In 2008, Lynch syndrome patients requested referrals to a support organization, prompting the authors to assess available resources. While general information about Lynch syndrome was readily available from multiple sources including the internet, updated, detailed information and psychosocial support was largely unavailable. Based on patient responses to a subsequent needs assessmen...
BACKGROUND Genetic counselling and testing for Lynch syndrome have recently been introduced in several South American countries, though yet not available in the public health care system. METHODS We compiled data from publications and hereditary cancer registries to characterize the Lynch syndrome mutation spectrum in South America. In total, data from 267 families that fulfilled the Amsterda...
Background It is known that metachronous colorectal cancer risk for Lynch syndrome patients with primary colon cancer is high and total colectomy is the preferred option [1]. However if the index primary cancer is in the rectum, management advice is complicated by considerations of worsening bowel function or stoma formation. To aid surgical decision-making, we estimated the risk of metachronou...
Mortality from colorectal cancer can be reduced by early diagnosis and by cancer prevention through polypectomy. These NCCN Guidelines for Colorectal Cancer Screening describe various colorectal screening modalities and recommended screening schedules for patients at average or increased risk of developing colorectal cancer. In addition, the guidelines provide recommendations for the management...
Colorectal cancer affects about 4.4% of the population and is a leading cause of cancer-related death in the United States. Approximately 10% to 20% of cases occur within a familial pattern, and Lynch syndrome is the most common hereditary colorectal cancer syndrome. Lynch syndrome is a hereditary predisposition to forming colorectal and extracolonic cancers, caused by a germline mutation in on...
Background Microsatellite instability (MSI) within colorectal cancers (CRC) may develop through inherited germline mutations in mismatch repair (MMR) genes (Lynch Syndrome) or sporadic epigenetic methylation of tumor suppressor or repair genes (methylator pathway). Although the molecular mechanisms in each pathway have been described, their associated precursor polyp burdens are not well-define...
Background Women with hereditary breast and ovarian cancer (HBOC) have an estimated 15-65% lifetime risk of ovarian cancer; similarly, women with Lynch syndrome have a 40-60% lifetime risk of endometrial cancer and a 10-12% lifetime risk of ovarian cancer. The aim of this study was to investigate the impact of genetic testing on risk-reducing behavior for gynecologic malignancies in women being...
The conference covered several contemporary topics like apoptosis, angiogenesis and several interesting and insightful talks were presented by the delegates. The keynote addresses ' Cancer predisposition', on the opening day by Dr. HT Lynch, the father of lynch syndrome, a hereditary non polyposis colorectal cancer (HNPCC) is a highlight of the symposium. There were several talks on dietary inf...
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