Nickel(0) catalyzed [4+2] cycloaddition of electron-deficient dienes to alkynes and subsequent aromatization gave highly substituted arenes. This formal inverse electron-demand Diels-Alder cycloaddition is attributed to the formation of a seven-membered nickelacycle from a diene and an alkyne.

During the positive-ion mode electrospray ionization mass spectrometry analysis of 1,4-diphenyl-3-benzoyl-1,4-dihydropyridines with methanol as the solvent, the major ion generated is one mass unit lower than the analyte, which can be rationalized as the oxidative aromatization of 1,4-dihydropyridines to pyridine cations.

A new method for the catalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner was developed for the first time. Under mild conditions, the domino Michael/aromatization/cyclization reaction worked well to afford the corresponding products in moderate to high yields with excellent enantioselectivities, some of which have promising cytotoxicity against cance...

A goal of aspirin therapy is to inhibit thromboxane production and platelet aggregation without inhibiting endothelial production of the vasodilator and anti-thrombotic prostacyclin. This study tested the hypothesis that extended-release aspirin (NHP-554C) would have increased selectivity for inhibition of basal and simulated thromboxane formation compared to immediate-release aspirin (ASA). Th...

BACKGROUND Dickkopf-1 (DKK-1) is a major regulator of the Wnt signaling pathway, involved in inflammation, atherogenesis, and the regulation of glucose metabolism. Because platelets are major contributors to circulating levels of DKK-1 in other clinical settings, we aimed at characterizing the platelet contribution to DKK-1 in type 2 diabetes mellitus (T2DM) and evaluating associations of DKK-1...

Objectives: To evaluate whether aspirin reduces the incidence and frequency of daily life myocardial ischaemia in a cohort of patients with chronic stable coronary artery disease. Setting: Tertiary referral centre. Methods: 60 patients with chronic stable coronary artery disease underwent 48 hour Holter monitoring to assess the incidence and frequency of daily life myocardial ischaemia. Those w...

OBJECTIVES The aim of our study was to assess whether acute, short-term hyperglycemia affects platelet reactivity in patients with Type II diabetes mellitus (T2DM). BACKGROUND Hyperglycemic spikes are thought to precipitate ischemic events in T2DM. Previous studies have shown in vivo platelet activation in diabetes; however, no studies have assessed whether acute in vivo hyperglycemia induces...

In recent years, there has been increasing recognition of the importance of steroid aromatization in organs besides the steroidogenic ones. Estrogens formed from C-19 precursors in peripheral tissues can clearly contribute to the levels of estrogens in the circulation, while aromatization in target cells may be an important determinant of the concentration of estrogens to which a particular pop...

In order to study the initial as well as the final steps in the aromatization of androgens to estrogens, highspecific activity [ 19-CSHs]androstenedione and testosterone were synthesized. Incubations of [ 19-CSHs]androstenedione with human placental microsomes resulted in the generation of [‘Hlwater, as a result of the dual hydroxylation at (2-19, and [’Hlformic acid reflecting final aromatizat...

This paper describes step-economic iodine-mediated construction of functionalized arylazopyrazoles in the presence of catalytic AgNO3 starting from simple β-ketoesters and two equivalents of arylhydrazines. This cascade reaction includes in situα-iodination of β-ketoesters, pyrazol-3-one formation, substitution with a nitrogen nucleophile, and oxidation/aromatization.