Understanding the molecular mechanisms behind regulation of chromatin folding through covalent modifications of the histone N-terminal tails is hampered by a lack of accessible chromatin containing precisely modified histones. We study the internal folding and intermolecular self-association of a chromatin system consisting of saturated 12-mer nucleosome arrays containing various combinations o...

0144-8617/$ see front matter Published by Elsevier doi:10.1016/j.carbpol.2010.01.045 q Product names are necessary to report factually on USDA neither guarantees nor warrants the standard o the name by the USDA implies no approval of the prod that may also be suitable. * Corresponding author. Tel.: +1 309 681 6354; fax E-mail address: [email protected] (R.L. Starch was acetylated with ...

The HMG-CoA reductase inhibitor simvastatin activates AMP-activated protein kinase (AMPK) and thereby induces histone acetylation. We postulated that combining with the deacetylase (HDAC) romidepsin would kill bladder cancer cells by inducing acetylation cooperatively. combination of induced robust apoptosis killed synergistically. In murine subcutaneous tumor models using MBT-2 cells, a 15-day...

Most isolates of Staphylococcus aureus produce a serotype 5 (CP5) or 8 (CP8) capsular polysaccharide. To investigate whether CP5 and CP8 differ in their biological properties, we created isogenic mutants of S. aureus Reynolds that expressed CP5, CP8, or no capsule. Biochemical analyses of CP5 and CP8 purified from the isogenic S. aureus strains were consistent with published structures. The deg...

The first and second Zagreb indices of a graph are equal, respectively, to the sum of squares of the vertex degrees, and the sum of the products of the degrees of pairs of adjacent vertices. We now consider analogous graph invariants, based on the second degrees of vertices (number of their second neighbors), called leap Zagreb indices. A number of their basic properties is established.

regioselective diels-alder reactions of acyl-1,4-benzoquinones 1 with, severally, isoprene, trans-piperylene,1-acetoxy-1,3-butadiene and 1-methoxy-1,3-butadiene gave the corresponding adducts 2 in high yield. treatment of the adducts 2 with manganese dioxide gave regiospecifically the corresponding 1,4-naphthoquinones 3. in several cases, the adducts of the acetylquinones afforded intermediates...