Exophilin A, a new antibacterial compound, was discovered in the culture of the marine microorganism Exophiala pisciphila NI10102, which was isolated from a marine sponge Mycale adhaerens. The absolute chemical structure of exophilin A was elucidated as a trimer of (3R,5R)-3,5-dihydroxydecanoic acid by spectroscopic methods and analyses of a degradative product. Exophilin A showed antimicrobial...

Dictyostelium discoideum amoebae can be induced to acquire a non-degradative resistance to the pea phytoalexin pisatin. The nysB sunD double mutant is blocked in the acquisition of this resistance. Using parasexual genetics it has been shown that sunD is a recessive mutation linked to nysB on linkage group VI.

Phenacein, an inhibitor of angiotensin-converting enzyme, has been isolated from the fermentation broth of a Streptomyces species belonging to the Streptomyces tanashiensis-zaomyceticus group. The inhibitor was shown to be 3,6-dihydroxy-1-phenazinecarboxylic acid by spectroscopic, degradative and synthetic methods.

Bracken, Pocker & Raistrick (1954) described the isolation of two nitrogen-containing products from different cultures of Penicillium cyclopium Westling. One of these, previously isolated from Penicillium viridicatum Westling by Cunningham & Freeman (1953) and named viridicatin, C15H11NO2, was shown to be 2,3-dihydroxy-4phenylquinoline or its keto-tautomer (I), by degradative methods and unequi...

A new quinone derivative, named epoxyquinophomopsin (1), was isolated from the EtOAc extract of the fermentation broth culture of an endophytic fungus Phomopsis sp. from Morus cathayana. Structure of compound 1 was determined mainly by NMR and mass spectral data. Biogenetically compound 1 can be regarded as a degradative product of the previously reported anthraquinone found in the fungus.

A degradative bacterium, M6, was isolated and presumptively identified as Plesiomonas sp. strain M6 was able to hydrolyze methyl parathion to p-nitrophenol. A novel organophosphate hydrolase gene designated mpd was selected from its genomic library prepared by shotgun cloning. The nucleotide sequence of the mpd gene was determined. The gene could be effectively expressed in Escherichia coli.

The Paenibacillus sp. strain PAMC 26794 was isolated from the tundra grasslands in Alaska for its high ability to degrade humic acids. We sequenced the PAMC 26794 genome to discover the degradative genes for natural humic substances and we propose the degradation pathway(s) of an abundant bacterial group (genus Paenibacillus) that inhabits cold environments.

In this article, the mathematical model used originally proposed by Bruce and co-workers was reviewed and extended. By assuming spherical symmetry of tumour, there were mathematical expressions in the form of partial differential equations along with some suitable conditions for density of proliferating tumor cells, quiescent tumor cells, surrounding tissue macromolecule (MM) and concentration ...

Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation. In this chapter, we discuss the current knowledge of the molecular mechanisms underlying phagosome formation and maturation in neutrophils. © 2003 Édit...

Comamonas testosteroni TK102 (NBRC 109938; JCM 19603) can utilize biphenyl as a sole carbon source and degrade polychlorinated biphenyls (PCBs). The complete nucleotide sequence of the TK102 genome was determined. TK102 possesses several integrative and conjugative element-like regions, and one of them carries biphenyl-degradative genes.