A study of the effect of nicorandil (N-2-(hydroxyethyl)nicotinamide nitrate, CAS 65141-46-0), a potassium channel and guanylatecyclase activator, upon preparations of rat was deferens and uterus, and guinea pig ileum was performed. Nicorandil does not modify rat isolated was deferens responses to noradrenaline (norepinephrine) and potassium. The drug exerts a non-competitive antagonist effect u...

The inhibitory effect of agmatine on electrically induced contractions was studied in vas deferens of Adra 2a transgenic mice lacking -adrenoceptors. Agmatine and clonidine caused a concentration-dependent inhibition of twitches. However, while agmatine showed a similar pIC value in control and transgenic mice, the pIC value for clonidine was about 30-fold lower in knockout mice. In both strain...

The vas deferens, a muscular conduit conveying spermatozoa from the epididymis to the urethra, has been used as a model tissue for smooth muscle pharmacological and physiological advancements. Many drugs, notably α-adrenergic antagonists, have effects on contractility and thus normal ejaculation, incurring significant side effects for patients that may interfere with compliance. A more thorough...

The inhibitory effect of agmatine on electrically induced contractions was studied in vas deferens of Adra 2a transgenic mice lacking alpha(2A)-adrenoceptors. Agmatine and clonidine caused a concentration-dependent inhibition of twitches. However, while agmatine showed a similar pIC(50) value in control and transgenic mice, the pIC(50) value for clonidine was about 30-fold lower in knockout mic...

thoracic duct is a duct that drains the lymph from the cisterna chily into the venous angle of the cranial vena vava. thoracic duct in the horse is situated on the right side, but in rare cases the left thoracic duct has been reported. in this report the course and left position of the thoracic duct in an embalmed donkey is described. regarding many anatomical similarities between horse and don...

background: precious fruits like jambul are neglected and wasted while environmental pollutants like lead intake remain overlooked. objective: the aim of this study was to investigate the effects of the jambul pulp extract on lead detrimental effects in pseudostratified epithelium and the stereocilia of mice epididymis and vas deferens. materials and methods: thirty young males mice (mus muscul...

Anatomic variations in forensic extrahepatic bile ducts is common. Knowledge of extrahepatic bile duct variations is important for surgeons in order to prevent iatrogenic damage during surgery. This study aims to determine the variations in extrahepatic bile ducts among 150 cadavers located at the Kerman Medicine Organization. We performed autopsies on 150 cadavers. Bile ducts were exposed an...

The distribution of the activity of seven acid glycosidases in the reproductive organs of the pheasant (Phasianus colchicus) was studied. The study was carried out on seven mature birds at the age of 11 months during the reproductive season (May). Significant (p<0.01) differences in acid glycosidase activity dependent on enzyme origin were observed. Generally, the highest activity of acid glyco...

background : the application of ventilation systems in industries and workplaces is with the aim of improving environmental conditions for employees. the lack of appropriate ventilation system components design and control methods result in the production of sound and vibration in most components. the purpose of this study was to determine the role of the pad isolator in controlling vibration a...

Abstract Introduction Congenital Bilateral Absence of the Vas Deferens (CBAVD) is a condition leading to obstructive azoospermia and male infertility. CBAVD associated with mutations in cystic fibrosis transmembrane conductance regulator (CFTR) gene. Unilateral (CUAVD), where only one vas deferens missing, also CFTR However, genetic causes both conditions are not fully understood warrant furthe...