Antimicrobial peptides (AMPs) have recently become widely publicized because they the potential to function in alternative therapies as “natural” antibiotics, with their main advantage being a broad spectrum of activity. The for antimicrobial treat diabetes mellitus (DM) has been reported. In type I (T1D), cathelicidin-related peptide (CRAMP), cathelicidin (CAMP) and mouse-β- defensin 14 (mBD14...

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Fungi are an emerging source of peptide antibiotics. With the availability of a large number of model fungal genome sequences, we can expect that more and more fungal defensin-like peptides (fDLPs) will be discovered by sequence similarity search. Here, we report a total of 69 new fDLPs encoded by 63 genes, in which a group of fDLPs derived from dermatophytes are defined as a new family (fDEF8)...

Human beta-defensin 3 has received great interest for possible pharmaceutical applications. To characterize the biology of this antimicrobial peptide, the mouse beta-defensin 14 has been selected as a prototypical model. This report provides definite evidence of true orthology between these defensins and reveals molecular diversity of a mammalian specific domain responsible for their antimicrob...

The effects of five antipathogenic plant peptides, wheat alpha-thionin, potato PTH1 defensin, barley LTP2 lipid transfer protein, and potato tuber DL1 and DL2 defensins, have been tested against phospholipid vesicles (liposomes). Wheat thionin very actively induces aggregation and leakage of negatively charged vesicles. LTP2 displays the same activities, although to a limited extent. Under cert...

We report the discovery of HD5-CD, an unprecedented C2-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys(II)-Cys(IV) (Cys(5)-Cys(20)) bonds located at the hydrophobic interface. This disulfide-locked dimeric assembly provides a new element of stru...

We found that sterile wounding of human skin induced epidermal expression of the antimicrobial (poly)peptides human beta-defensin-3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor through activation of the epidermal growth factor receptor. After skin wounding, the receptor was activated by heparin-binding epidermal growth factor that was released by a met...

The occurrence of caecal nematode, Subulura brumpti has become more common in quails being maintained in commercial farms in Tamil Nadu, India. Two trials were carried out to study the biology and pathology of S. brumpti in quails. In the first trial, eight grower quails were divided into two groups (T1 and T2) comprising of four birds each. The birds belonged to the group T1 was infected with ...

Von Liebig noted in his most famous book that agriculture’s principal objective is the production of digestible N (1). This task was particularly challenging in all traditional (pre-industrial) agricultures. They had 3 ways in which to provide N for crops: i) recycling of organic wastes (mainly crop residues and animal and human wastes); ii) crop rotations including N-fixing leguminous species;...

Study objectives: Breath-to-breath variability is not purely random but is, instead, characterized by correlations on shortand long-term scales. Shortterm correlations might reflect intact metabolic-control mechanisms. To investigate whether the higher variability of breathing during rapid eye movement (REM) compared to non-REM (NREM) sleep is of random or nonrandom nature—reflecting an altered...