The incidence of deep-vein thrombosis and the need for thromboprophylaxis following isolated trauma below the knee is uncertain. We have investigated this with a prospective randomised double-blind controlled trial using low molecular weight heparin with saline injection as placebo in patients aged between 18 and 75 years who had sustained an isolated fracture below the knee which required oper...

BACKGROUND AND OBJECTIVE The potential utility of D-dimer measurements for the diagnosis of deep vein thrombosis became evident soon after the development of reliable commercial assays. The purpose of this review is to outline some critical aspects affecting cost-effectiveness of D-dimer measurements in the diagnosis of deep vein thrombosis (DVT). METHODS The authors have been working in this...

OBJECTIVE To evaluate the efficacy and safety of two subcutaneous prophylactic regimens for postoperative deep vein thrombosis after total hip replacement. DESIGN Prospective open randomised multicentre trial. SETTING 28 European departments of orthopaedic surgery. INTERVENTION All patients had bilateral phlebography 10 days after surgery. 31 patients receiving low molecular weight hepari...

Deep vein thrombosis (DVT) represents the formation of a blood clot in one of the deep veins of our body, predominantly occurring in the legs. According to international guidelines, the goal of the treatment in deep vein thrombosis is to prevent the progression and the recurrences of thrombotic process. The aim of this article is to explain the pathogenetic mechanism of deep vein thrombosis and...

Two study groups were identified in a total of 250 patients with confirmed deep-vein thrombosis treated at the University of Padua, Padua, Italy, drawn from 1159 consecutive patients seen 1985 to 1991 for suspected thrombosis. Out of a regional population of 350,000, general practitioners referred all cases with suspected deep-vein thrombosis to the treatment center in Padua. The diagnosis was ...

In this article, we present a rare case of calcified deep vein thrombosis in a 42-year-old female patient with frequent relapses of pulmonary sarcoidosis since 1995, for which she was on maintenance therapy with corticosteroids and with consequential secondary diabetes. Recent femoral vein thrombosis was diagnosed with color Doppler in 2012. At the same time, calcified occlusive thrombus in ven...

Pulmonary thromboembolism (PTE) is a clinically critical disease, misdiagnosis or delayed diagnosis of which can lead to increased rate of mortality. For prevention of recurrence of PTE, recognition of its risk factors or underlying diseases is of great importance. PTE is common in patients with cancer and has high morbidity and mortality rates. Although cancer is a lethal condition, PTE accele...

It is well known that deep vein thrombosis of the upper extremities is linked to high morbidity/mortality, resulting in 12-20% of all documented pulmonary embolism; however, there are few data about thromboembolism originating from a vein and/or a branch of a superficial vein of the upper extremities. Pulmonary embolism secondary to upper limb superficial vein thrombosis (not combined with uppe...

When is Dementia Presenile? J. A. Snowdon, M.R.A.C.P.; P. K. Bridges, M.D., D.P.M ............................. 465 Research in Psychiatry C. P. B. Brook, D.P.M.; A. Tarnopolsky, M.D. 465 Speaking Valve for Alttachment to a Tracheostomy Tube F. M. Emery, F.F.A. R.C.S ................. 466 Effect of Intravenous Infusion of Acetylsalicylic Acid on Renal Function M. Robert, and others ...............

Antiphospholipid syndrome (APS) is an acquired systemic autoimmune disorder characterized by a combination of clinical criteria, including vascular thrombosis or pregnancy morbidity and elevated antiphospholipid antibody titers. It is one of the causes of deep vein thrombosis and pulmonary embolism that can be critical due to the mortality risk. Overall recurrence of thromboembolism is very low...