Although liver disease seems to be stable in most patients who are infected with lamivudine-resistant mutant hepatitis B virus (HBV) in the short term, it may progress to more-advanced disease in some patients. In our pilot study, we investigated the efficacy of oral ganciclovir for the treatment of lamivudine-resistant HBV infection. Six patients infected with lamivudine-resistant HBV (3 patie...

Hepatocellular adenoma is a benign neoplasm that almost always occurs in a histologically normal liver. We report the finding of a hepatocellular adenoma in the cirrhotic liver of a 56year-old female patient. A hypervascular nodule was detected by computed tomography (CT) scan and magnetic resonance imaging (MRI) conducted as part of a pre-transplant evaluation. The patient subsequently underwe...

Situs inversus (SI) is a rare congenital disorder with a complete mirror image of thoracic and abdominal organs. In adults with SI and decompensated cirrhosis experience with liver transplantation is limited. Orthotopic liver transplantation (OLT) in an adult with cirrhosis using a technique where the recipient liver was placed using a 90-degree rotation of the graft was previously reported by ...

Alcoholic liver disease (ALD) is a spectrum ranging from simple hepatic steatosis to alcoholic hepatitis and cirrhosis. Patients with severe alcoholic hepatitis can have clinical presentation almost similar to those with decompensated cirrhosis. Scoring with models like Maddrey discriminant function, a model for end-stage liver disease, Glasgow alcoholic hepatitis score, and Lille model are hel...

The present study was performed to investigate the renal handling of water in rats with decompensated liver cirrhosis. Liver cirrhosis was induced by intraperitoneal administration of carbon tetrachloride twice weekly for 16 wk. Control rats were treated with vehicle. The cirrhotic rats developed severe disturbances in water homeostasis: urine production was decreased and hyperosmotic, the rats...

A 69-year-old man was referred to our hospital because of hepatic failure after extracorporeal shock wave lithotripsy. The diagnosis of urinary tract infection and fungemia due to Candida albicans associated with decompensated liver cirrhosis and renal failure was made. Bilateral endogenous endophthalmitis developed during hospitalization. Candidemia, endophthalmitis and hepatorenal failure imp...

Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the Child-Pugh score. Plasma concentrations of AOPPs and inflammatory markers such ...

Aeromonas hydrophila is a low-virulence gram-negative bacillus. It has never been reported as a pathogen of non-traumatic acute osteomyelitis in a cirrhotic patient. Herein, we reported on a case of decompensated liver cirrhosis with Aeromonas hydrophila infection presenting as acute gastroenteritis and non-traumatic acute osteomyelitis. It has been shown that Aeromonas bacteremia usually affec...

Background and AimsCirrhosis is associated with changes in gut microbiome composition. Although acute-on-chronic liver failure (ACLF) the most severe clinical stage of cirrhosis, there lack information about alterations ACLF using quantitative metagenomics. We investigated patients cirrhosis encompassing whole spectrum disease (compensated, acutely decompensated without ACLF, ACLF). A group hea...

Aim Malnutrition, which increases the risk of liver disease-related events and mortality, is a serious complication in cirrhosis. This study aimed to investigate whether geriatric nutritional index (GNRI) could predict long-term prognosis patients with Methods We retrospectively evaluated 266 cirrhosis classified them into two groups based on baseline GNRI scores: (≤98, n = 104) no-risk (&g...