The study comprised 25 patients with Syndromic genetic hearing loss. They were selected from the Audiology Unit, Faculty of Medicine, and the Human Genetics clinic, Medical Research Institute, , Alexandria University. Their ages ranged from 2.5 to 19 years. Males were more affected than females (M/F ratio = 2:1). T he high parental consanguinity (63.2 %) emphasizes the contribution of autosomal...

Deafness affects ∼2 in 1000 children and is one of the most common congenital impairments. Permanent hearing loss can be treated by fitting hearing aids. More severe to profound deafness is an indication for cochlear implantation. Although newborn hearing screening programs have increased the identification of asymmetric hearing loss, parents and caregivers of children with single-sided deafnes...

The otological complications of leukemia are common, but rarely are they given much consideration in discussions of the clinical aspects of leukemia. During the past several years the frequency with which deafness, tinnitus, and vertigo have developed in many of our patients has prompted us to investigate the incidence and type of involvement which occurs in this disorder. The aural manifestati...

a study to evaluate the reproductive performance of abergelle goat was carried out at sekota district of amhara national regional state. on-farm flocks from two peasant associations were monitored for two years to collect data. data collected included identification number of doe and kid, birth / kidding date, kid birth weight, sex of kid, post partum doe weight, litter size, parity of doe. dat...

The myosin VII motor protein has recently been found to have a role in cell adhesion. This new function is conserved from amoebae to man and provides an explanation for deafness in Usher syndrome patients.

It has long been recognized that heredity plays a major role in hearing impairment. Although the facts about the genetic basis of hearing loss have fascinated both clinicians and geneticists for a long time, it is only within the last few years that the genes and molecular mechanisms underlying deafness have begun to be discovered. There is a great deal of genetic heterogeneity in deafness. Thi...

The bacterial parD toxin-antitoxin system of plasmid R1 encodes two proteins, the Kid toxin and its cognate antitoxin, Kis. Kid cleaves RNA and inhibits protein synthesis and cell growth in Escherichia coli. Here, we show that Kid promotes RNA degradation and inhibition of protein synthesis in rabbit reticulocyte lysates. These new activities of the Kid toxin were counteracted by the Kis antito...

A family which is part of a large kindred in which a sex-linked recessive syndrome manifested by profound deafness and partial albinism was reported by Margolis (1962) and independently by Ziprkowski et al. (1962). According to their reports hearing impairment was not found in carriers. The family first came to our attention because of deafness of a male child (III.5, Fig. 1) and later for gene...

delay the diagnosis and treatment [2, 3, 9]. The audiovestibular prognosis depends on steroid treatment within the first month of the symptoms [3], but hearing loss may progress to profound bilateral deafness if the patient has repeated attacks [3–5]. Our patient’s initial ocular symptoms occurred 4 yrs before her hearing loss. This was the clue leading to diagnosis and appropriate treatment wi...