BACKGROUND Netrin-1 may promote colorectal and breast tumorigenesis, by inhibiting apoptosis induced by its dependence receptors, deleted in colorectal cancer (DCC) and uncoordinated-5-homolog (UNC5H). The status of netrin-1 and its receptors in non-small cell lung cancer (NSCLC) was unknown. METHODS The levels of netrin-1 and its receptors were analyzed in a panel of 92 NSCLC and 25 human lu...

The phylogenetically conserved Netrin family of chemoattractants signal outgrowth and attractive turning of commissural axons through the Deleted in Colorectal Carcinoma (DCC) family of receptors. Src family kinases are thought to be major signaling effectors of Netrin/DCC. In vertebrates, Src and the closely related Fyn kinases phosphorylate DCC and form a receptor-bound signaling complex lead...

Paranodal axoglial junctions are essential for the segregation of myelinated axons into distinct domains and efficient conduction of action potentials. Here, we show that netrin-1 and deleted in colorectal cancer (DCC) are enriched at the paranode in CNS myelin. We then address whether netrin-1 signaling influences paranodal adhesion between oligodendrocytes and axons. In the absence of netrin-...

Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, and RGC axons express the netrin receptor, DCC (deleted in colorectal cancer). I...

Social networks, such as virtual communities, permit connections between citizen and government. Integrating consultative and deliberative environments for popular participation in democratic issues and creating virtual communities for warranting better relationship among members make it possible to model decisionmaking processes. For this reason, the Democratic Citizenship Community (DCC) was ...

We have investigated the effect of friction on the DCC domain formation. We solve the Newton equation of motion for the O(4) fields, with quenched initial condition. The initial fields are randomly distributed in a Gaussian form. In one dimensional expansion, on the average, large DCC domains can not be formed. However, in some particular orbits, large instabilities may occur. This possibility ...

Dosage compensation refers to the equalization of X-linked gene transcription among heterogametic and homogametic sexes. In Drosophila, the dosage compensation complex (DCC) mediates the twofold hypertranscription of the single male X chromosome. Loss-of-function mutations at any DCC protein-coding gene are male lethal. Here we report a population genetic analysis suggesting that four of the fi...

One of the features of a financial market, the stock market, in particular, is the market sentiment which is the overall attitude of investors toward a particular security or financial market. Investors always seek to create a portfolio with minimum risk while maintaining the expected return level. Therefore, perceiving the relationship between the stock returns and markets returns can be helpf...

Since 2008, X-ray structure depositions to the Protein Data Bank archive (PDB) have required submission of experimental data in the form of structure factor files. RCSB PDB has developed the program DCC to allow worldwide PDB (wwPDB; http://wwpdb.org) biocurators, using a single command-line program, to invoke a number of third-party software packages to compare the model file with the experime...

We consider the quantum state describing the Disoriented Chiral Condensate (DCC), which may be produced in high energy collisions. We show how a mean field treatment of the quantum equations corresponding to the classical linear sigma model leads to a squeezed state description of the pions emerging from the DCC. We examine various squeezed and coherent state descriptions of those pions with pa...