PURPOSE To determine retinal vesicular glutamate transporter 3 (VGLUT3) expression alterations in a mouse model of progressive optic neuropathy (glaucoma). METHODS Tissue specimens were obtained from age-matched DBA/2J and control C57BL/6J mice for western blot analysis. Enucleated globes from DBA/2J, C57BL/6J, and BALB/cJ mice were fixed in formalin, paraffin-embedded, and sectioned for VGLU...

The rational design of a set of hemin/G-quadruplex (hGQ)–dopamine binding aptamer (DBA) conjugates, acting as nucleoapzymes, is described. The nucleoapzyme constructs consist of a hGQ DNAzyme as a catalytic unit and DBA as a substrate binding unit that are brought into spatial proximity by a duplex scaffold composed of complementary oligonucleotide strands. When the hGQ unit is linked to the du...

This study builds on the findings that physical activity, such as wheel running in mice, enhances cell proliferation and neurogenesis in the adult hippocampus of the common mouse strain C57BL/6, and that the baseline level of neurogenesis varies by strain, being considerably lower in DBA/2. Because C57BL/6 and DBA/2 are important as the parental strains of the BXD recombinant inbred cross which...

dentin bonding agents (dba) have been used as root-end filling materials. present study evaluated the effects of polymerized dba on secretion of pro-inflammatory cytokines by normal human monocytes. in this study, monocytes were directly isolated from human peripheral blood, and exposed to cured scotch bond 1 (single bond) and prime and bond for 36 and 72 hours. secretion of il-1β and tnf-α in ...

We study the problem of linear dimension reduction for classification, with a focus on sufficient dimension reduction, i.e., finding subspaces without loss of discrimination power. First, we formulate the concept of sufficient subspace for classification in parallel terms as for regression. Then we present a new method to estimate the smallest sufficient subspace based on an improvement of deci...

The M variant of encephalomyocarditis virus produces a diabetes mellitus-like disease in DBA/2 mice but not in animals of the C3H strain. Fewer than one-third of infected F(1) (DBA/2 x C3H) progeny exhibit the disease, whereas the prevalence in backcrosses (F(1) x DBA/2, F(1) x C3H) is comparable to the parental inbred strain. Thus, the mode of inheritance of the diabetic predisposition appears...

Mutations affecting genes encoding ribosomal proteins cause Diamond Blackfan anemia (DBA), a rare congenital syndrome associated with physical anomalies, short stature, red cell aplasia, and an increased risk of malignancy. p53 activation has been identified as a key component in the pathophysiology of DBA after cellular and molecular studies of knockdown cellular and animal models of DBA and o...

An Ethernet passive optical network (EPON) is an access that allows a higher data rate with low power consumption. To improve energy savings for EPON, the sleep and doze modes units (ONUs) play pivotal role. Many prediction schemes have been proposed to control these modes. increase accuracy, this study proposes energy-efficient approach uses support vector regression (SVR) model. A dynamic ban...

Diamond-Blackfan Anemia (DBA) is a congenital erythroid aplasia characterized as a normochromic macrocytic anemia with a selective deficiency in red blood cell precursors in otherwise normocelullar bone marrow. DBA is known to be associated with mental retardation and learning disabilities. Although comorbidities with other psychiatric conditions have not been reported in the existing literatur...

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Among these genes, ribosomal protein S19 (RPS19) is mutated most frequently. Generation of animal models for diseases like DBA is challenging because the phenotype is highly dependent on the level of RPS19 down-regulation. We report the generatio...